The Library
ATP-mediated signalling in the central synapses
Tools
Lalo, Ulyana and Pankratov, Yuriy (2023) ATP-mediated signalling in the central synapses. Neuropharmacology, 229 . 109477. doi:10.1016/j.neuropharm.2023.109477 ISSN 0028-3908.
|
PDF
WRAP-ATP-mediated-signalling-central-synapses-2023.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (678Kb) | Preview |
Official URL: https://doi.org/10.1016/j.neuropharm.2023.109477
Abstract
ATP released from the synaptic terminals and astrocytes can activate neuronal P2 receptors at a variety of locations across the CNS. Although the postsynaptic ATP-mediated signalling does not bring a major contribution into the excitatory transmission, it is instrumental for slow and diffuse modulation of synaptic dynamics and neuronal firing in many CNS areas. Neuronal P2X and P2Y receptors can be activated by ATP released from the synaptic terminals, astrocytes and microglia and thereby can participate in the regulation of synaptic homeostasis and plasticity. There is growing evidence of importance of purinergic regulation of synaptic transmission in different physiological and pathological contexts. Here, we review the main mechanisms underlying the complexity and diversity of purinergic signalling and purinergic modulation in central neurons. [Abstract copyright: Copyright © 2023. Published by Elsevier Ltd.]
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Neuropharmacology | ||||||||
Publisher: | Elsevier | ||||||||
ISSN: | 0028-3908 | ||||||||
Official Date: | 15 May 2023 | ||||||||
Dates: |
|
||||||||
Volume: | 229 | ||||||||
Article Number: | 109477 | ||||||||
DOI: | 10.1016/j.neuropharm.2023.109477 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 11 April 2023 | ||||||||
Date of first compliant Open Access: | 24 February 2024 |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year