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Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products
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Bayless, Adam M., Chen, Sisi, Ogden, Sam C., Xu, Xiaoyan, Sidda, John D., Manik, Mohammad K., Li, Sulin, Kobe, Bostjan, Ve, Thomas, Song, Lijiang, Grant, Murray R., Wan, Li and Nishimura, Marc T. (2023) Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products. Science Advances, 9 (11). eade8487. doi:10.1126/sciadv.ade8487 ISSN 2375-2548.
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Official URL: https://doi.org/10.1126/sciadv.ade8487
Abstract
Toll/interleukin-1 receptor (TIR) domain proteins function in cell death and immunity. In plants and bacteria, TIR domains are often enzymes that produce isomers of cyclic adenosine 5′-diphosphate–ribose (cADPR) as putative immune signaling molecules. The identity and functional conservation of cADPR isomer signals is unclear. A previous report found that a plant TIR could cross-activate the prokaryotic Thoeris TIR–immune system, suggesting the conservation of plant and prokaryotic TIR-immune signals. Here, we generate autoactive Thoeris TIRs and test the converse hypothesis: Do prokaryotic Thoeris TIRs also cross-activate plant TIR immunity? Using in planta and in vitro assays, we find that Thoeris and plant TIRs generate overlapping sets of cADPR isomers and further clarify how plant and Thoeris TIRs activate the Thoeris system via producing 3′cADPR. This study demonstrates that the TIR signaling requirements for plant and prokaryotic immune systems are distinct and that TIRs across kingdoms generate a diversity of small-molecule products.
| Item Type: | Journal Article | |||||||||||||||||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QK Botany S Agriculture > SB Plant culture |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Plant immunology, Phytopathogenic microorganisms, Prokaryotes, Cell death | |||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Science Advances | |||||||||||||||||||||||||||||||||||||||||||||
| Publisher: | American Association for the Advancement of Science (AAAS) | |||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 2375-2548 | |||||||||||||||||||||||||||||||||||||||||||||
| Official Date: | 17 March 2023 | |||||||||||||||||||||||||||||||||||||||||||||
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| Volume: | 9 | |||||||||||||||||||||||||||||||||||||||||||||
| Number: | 11 | |||||||||||||||||||||||||||||||||||||||||||||
| Article Number: | eade8487 | |||||||||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1126/sciadv.ade8487 | |||||||||||||||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||||||||||||||||||||
| Date of first compliant deposit: | 20 July 2023 | |||||||||||||||||||||||||||||||||||||||||||||
| Date of first compliant Open Access: | 20 July 2023 | |||||||||||||||||||||||||||||||||||||||||||||
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