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Bacterial catabolism of membrane phospholipids links marine biogeochemical cycles
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Westermann, Linda, Lidbury , Ian D. E. A., Li, Chun-Yang, Wang, Ning, Murphy, Andrew R. J., del Mar Aguilo Ferretjans, Maria, Quareshy, Mussa, Shanmugan, Muralidharan, Torcello-Requena, Alberto, Silvano, Eleonora, Zhang, Yu-Zhong, Blindauer, Claudia A., Chen, Yin and Scanlan, David J. (2023) Bacterial catabolism of membrane phospholipids links marine biogeochemical cycles. Science Advances, 9 (17). eadf5122. doi:10.1126/sciadv.adf5122 ISSN 2375-2548.
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Official URL: https://doi.org/10.1126/sciadv.adf5122
Abstract
In marine systems, the availability of inorganic phosphate can limit primary production leading to bacterial and phytoplankton utilization of the plethora of organic forms available. Among these are phospholipids that form the lipid bilayer of all cells as well as released extracellular vesicles. However, information on phospholipid degradation is almost nonexistent despite their relevance for biogeochemical cycling. Here, we identify complete catabolic pathways for the degradation of the common phospholipid headgroups phosphocholine (PC) and phosphorylethanolamine (PE) in marine bacteria. Using Phaeobacter sp. MED193 as a model, we provide genetic and biochemical evidence that extracellular hydrolysis of phospholipids liberates the nitrogen-containing substrates ethanolamine and choline. Transporters for ethanolamine (EtoX) and choline (BetT) are ubiquitous and highly expressed in the global ocean throughout the water column, highlighting the importance of phospholipid and especially PE catabolism in situ. Thus, catabolic activation of the ethanolamine and choline degradation pathways, subsequent to phospholipid metabolism, specifically links, and hence unites, the phosphorus, nitrogen, and carbon cycles.
| Item Type: | Journal Article | ||||||
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| Alternative Title: | |||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| Journal or Publication Title: | Science Advances | ||||||
| Publisher: | American Association for the Advancement of Science | ||||||
| ISSN: | 2375-2548 | ||||||
| Official Date: | 26 April 2023 | ||||||
| Dates: |
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| Volume: | 9 | ||||||
| Number: | 17 | ||||||
| Article Number: | eadf5122 | ||||||
| DOI: | 10.1126/sciadv.adf5122 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 4 April 2023 | ||||||
| Date of first compliant Open Access: | 6 June 2023 | ||||||
| Related URLs: |
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