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Suicidal thoughts and behaviors in patients with chronic pain, with and without co-occurring opioid use disorder
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Cheatle, Martin D., Giordano, Nicholas A., Themelis, Kristy and Tang, Nicole K. Y. (2023) Suicidal thoughts and behaviors in patients with chronic pain, with and without co-occurring opioid use disorder. Pain Medicine . pnad043. doi:10.1093/pm/pnad043 ISSN 1526-2375. (In Press)
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WRAP-suicidal-thoughts-behaviors-patients-chronic-pain-with-without-co-occurring-opioid-use-disorder-Tang-2023.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 4 April 2024. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Download (784Kb) |
Official URL: https://doi.org/10.1093/pm/pnad043
Abstract
Background:
Individuals with chronic pain and a co-occurring substance use disorder present higher risk of suicide, but the individual and joint impacts of chronic pain and substance use disorders on suicide risk are not well defined. The objective of this study was to exam the factors associated with suicidal thoughts and behaviors in a cohort of patients with chronic non-cancer pain (CNCP), with or without concomitant opioid use disorder (OUD).
Design:
Cross sectional cohort design
Setting:
Primary care clinics, pain clinics, and substance abuse treatment facilities in Pennsylvania, Washington, and Utah
Subjects:
609 adults with CNCP treated with long-term opioid therapy (>/= 6 months) who either developed an OUD (cases, n = 175) or displayed no evidence of OUD (controls, n = 434).
Methods:
The predicted outcome was elevated suicidal behavior in patients with CNCP as indicated by a Suicide Behavior Questionnaire-Revised (SBQ-R) score of 8 or above. The presence of CNCP and OUD were key predictors. Covariates included demographics, pain severity, psychiatric history, pain coping, social support, depression, pain catastrophizing and mental defeat.
Results:
Participants with CNCP and co-occurring OUD had an increased odds ratio of 3.44 in reporting elevated suicide scores as compared to participants with chronic pain only. Multivariable modeling revealed that mental defeat, pain catastrophizing, depression, and having chronic pain, and co-occurring OUD significantly increased the odds of elevated suicide scores.
Conclusions:
Patients with CNCP and co-morbid OUD are associated with a 3-fold increase in risk of suicide.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RB Pathology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | |||||||||
| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Chronic pain -- Patients, Opioid abuse, Suicide -- Risk factors | |||||||||
| Journal or Publication Title: | Pain Medicine | |||||||||
| Publisher: | Wiley-Blackwell Publishing, Inc. | |||||||||
| ISSN: | 1526-2375 | |||||||||
| Official Date: | 4 April 2023 | |||||||||
| Dates: |
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| Article Number: | pnad043 | |||||||||
| DOI: | 10.1093/pm/pnad043 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | In Press | |||||||||
| Reuse Statement (publisher, data, author rights): | This is a pre-copyedited, author-produced version of an article accepted for publication in Pain Medicine following peer review. The version of record Martin D Cheatle, PhD, Nicholas A Giordano, PhD, RN, Kristy Themelis, PhD, Nicole K Y Tang, DPhil, Suicidal thoughts and behaviors in Patients with Chronic Pain, with and without co-occurring Opioid Use Disorder, Pain Medicine, 2023;, pnad043, is available online at: https://doi.org/10.1093/pm/pnad043 | |||||||||
| Access rights to Published version: | Free Access (unspecified licence, 'bronze OA') | |||||||||
| Date of first compliant deposit: | 18 April 2023 | |||||||||
| RIOXX Funder/Project Grant: |
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