The Library
The synthesis and analysis of complex poly(2-oxazoline) architectures
Tools
Hayes, Graham (2022) The synthesis and analysis of complex poly(2-oxazoline) architectures. PhD thesis, University of Warwick.
|
PDF
WRAP_THESIS_Hayes_2022.pdf - Submitted Version - Requires a PDF viewer. Download (9Mb) | Preview |
Official URL: http://webcat.warwick.ac.uk/record=b3884135
Abstract
Poly(2-oxazoline)s are a diverse polymer type that are synthesised via the cationic ring-opening polymerisation of 2-oxazoline monomers. The diversity of this polymer class stems from the wide range of functionalities that can be installed at both polymeric chain ends, as well as the monomer R group. This potential functionality can be used to access complex polymeric architectures that have a wide range of possible applications. In Chapter 1 of this thesis, a literature review of the synthesis and diversity of poly(2-oxazoline)s is firstly discussed, followed by discussion of some more complex poly(2-oxazoline) architectures. In Chapter 2, star polymers are synthesised using a bisfunctional 2-oxazoline monomer, and their potential for drug encapsulation is explored. Then, the same cross-linker is used to synthesise branched poly(2-oxazoline) structures. The analysis of these complex structures with advanced viscosity gel permeation chromatography is then discussed. In Chapter 3, poly(2-oxazoline)s are combined with acrylates to form hybrid block copolymers which can act as AB type macromonomers to form step-growth and cyclic polymers. The effect of various parameters on the ratio of step-growth to cyclic product is discussed, followed by advanced gel permeation chromatography analysis of the products and discussion on their aqueous self-assembly. In Chapter 4, a 2-oxazoline containing an amine on the R group is synthesised and polymerised to form statistical and block copolymers that can be glycosylated. These polymers are then tested for gene transfection and cell viability. Lastly in Chapter 5, a summary and conclusion are provided as well as an outlook on the future of poly(2-oxazoline)s.
Item Type: | Thesis (PhD) | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Polymerization, Branched polymers, Crosslinking (Polymerization), Crosslinked polymers, Block copolymers | ||||
Official Date: | September 2022 | ||||
Dates: |
|
||||
Institution: | University of Warwick | ||||
Theses Department: | Department of Chemistry | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Becer, C. Remzi | ||||
Format of File: | |||||
Extent: | 263 pages : illustrations, charts | ||||
Language: | eng |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |