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Anionic synthietic polymers prevent bacteriophage infection
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Marton, Huba L., Kilbride, Peter, Ahmad, Ashfaq, Sagona, Antonia P. and Gibson, Matthew I. (2023) Anionic synthietic polymers prevent bacteriophage infection. Journal of the American Chemical Society, 145 (16). pp. 8794-8799. doi:10.1021/jacs.3c01874 ISSN 0002-7863.
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WRAP-anionic-synthietic-polymers-prevent-bacteriophage-infection-2023.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2929Kb) | Preview |
Official URL: http://dx.doi.org/10.1021/jacs.3c01874
Abstract
Bioprocessing and biotechnology exploit microorganisms (such as bacteria) for the production of chemicals, biologics, therapies, and food. A major unmet challenge is that bacteriophage (phage) contamination compromises products and necessitates shut-downs and extensive decontamination using nonspecific disinfectants. Here we demonstrate that poly(acrylic acid) prevents phage-induced killing of bacterial hosts, prevents phage replication, and that induction of recombinant protein expression is not affected by the presence of the polymer. Poly(acrylic acid) was more active than poly(methacrylic acid), and poly(styrenesulfonate) had no activity showing the importance of the carboxylic acids. Initial evidence supported a virustatic, not virucidal, mechanism of action. This simple, low-cost, mass-produced additive offers a practical, scalable, and easy to implement solution to reduce phage contamination.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Bacteria, Polymers, Bacteriophages, Communicable diseases, Addition polymerization, Polymerization | |||||||||||||||
| Journal or Publication Title: | Journal of the American Chemical Society | |||||||||||||||
| Publisher: | American Chemical Society | |||||||||||||||
| ISSN: | 0002-7863 | |||||||||||||||
| Official Date: | 26 April 2023 | |||||||||||||||
| Dates: |
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| Volume: | 145 | |||||||||||||||
| Number: | 16 | |||||||||||||||
| Page Range: | pp. 8794-8799 | |||||||||||||||
| DOI: | 10.1021/jacs.3c01874 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 20 April 2023 | |||||||||||||||
| Date of first compliant Open Access: | 21 April 2023 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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