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The role of the vasculature in heart failure
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Joshi, Mithilesh, Tran, Patrick, Barber, Thomas M., Ayub, Waqar, Kuehl, Michael and Banerjee, Prithwish (2023) The role of the vasculature in heart failure. Current Heart Failure Reports, 20 . pp. 179-190. doi:10.1007/s11897-023-00602-4 ISSN 1546-9530.
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WRAP-Role-vasculature-heart-failure-23.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 9 May 2024. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Download (943Kb) |
Official URL: https://doi.org/10.1007/s11897-023-00602-4
Abstract
The contribution of the vasculature in the development and progression of heart failure (HF) syndromes is poorly understood and often neglected. Incorporating both arterial and venous systems, the vasculature plays a significant role in the regulation of blood flow throughout the body in meeting its metabolic requirements. A deterioration or imbalance between the cardiac and vascular interaction can precipitate acute decompensated HF in both preserved and reduced ejection fraction phenotypes. This is characterised by the increasingly recognised concept of ventricular-arterial coupling: a well-balanced relationship between ventricular and vascular stiffness, which has major implications in HF. Often, the cause of decompensation is unknown, with international guidelines mainly centred on arrhythmia, infection, acute coronary syndrome and its mechanical complications as common causes of decompensation; the vascular component is often underrecognised. A better understanding of the vascular contribution in cardiovascular failure can improve risk stratification, earlier diagnosis and facilitate earlier optimal treatment. This review focuses on the role of the vasculature by integrating the concepts of ventricular-arterial coupling, arterial stiffness and venous return in a failing heart.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Heart failure, Blood-vessels, Arteries | ||||||||
Journal or Publication Title: | Current Heart Failure Reports | ||||||||
Publisher: | Springer | ||||||||
ISSN: | 1546-9530 | ||||||||
Official Date: | June 2023 | ||||||||
Dates: |
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Volume: | 20 | ||||||||
Page Range: | pp. 179-190 | ||||||||
DOI: | 10.1007/s11897-023-00602-4 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Re-use Statement: | “This version of the article has been accepted for publication, after peer review (when applicable) but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11897-023-00602-4. Use of this Accepted Version is subject to the publisher’s Accepted Manuscript terms of use https://www.springernature.com/gp/open-research/policies/acceptedmanuscript-terms”." | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 30 May 2023 | ||||||||
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