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PIN structures shed light on their mechanism of auxin efflux
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Joshi, Chitra and Napier, Richard (2023) PIN structures shed light on their mechanism of auxin efflux. Journal of Experimental Botany, 74 (15). pp. 4377-4383. doi:10.1093/jxb/erad185 ISSN 0022-0957.
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Official URL: https://doi.org/10.1093/jxb/erad185
Abstract
Polar auxin transport is a quintessential feature of higher plant physiology and it has been known for many years that some of the primary drivers of polar auxin transport are the PIN-formed (PIN) auxin efflux proteins. Formative research established many key biochemical features of the transport system and discovered inhibitors such as 1-naphthylphthalamic acid (NPA), but the mechanism of action of PINs has remained elusive. This changed in 2022 with the publication of high-resolution structures of the membrane-spanning domains of three PIN proteins. The atomic structures and associated activity assays reveal that PINs use an elevator mechanism to transport auxin anions out of the cell. NPA was shown to be a competitive inhibitor that traps PINs in their inward-open conformation. The secrets of the hydrophilic cytoplasmic loop of PIN proteins remain to be discovered.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QK Botany | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Library of Congress Subject Headings (LCSH): | Auxin, Auxin -- Molecular aspects, Plant physiology, Plants -- Development, Botanical chemistry, Proteins -- Structure | ||||||||
Journal or Publication Title: | Journal of Experimental Botany | ||||||||
Publisher: | Oxford University Press | ||||||||
ISSN: | 0022-0957 | ||||||||
Official Date: | August 2023 | ||||||||
Dates: |
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Volume: | 74 | ||||||||
Number: | 15 | ||||||||
Page Range: | pp. 4377-4383 | ||||||||
DOI: | 10.1093/jxb/erad185 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 27 April 2023 | ||||||||
RIOXX Funder/Project Grant: |
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