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Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition
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(2023) Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition. Nature Communications, 14 (1). 2568. doi:10.1038/s41467-023-38103-6 ISSN 2041-1723.
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Official URL: https://doi.org/10.1038/s41467-023-38103-6
Abstract
In both plants and animals, nucleotide-binding leucine-rich repeat (NLR) immune receptors play critical roles in pathogen recognition and activation of innate immunity. In plants, NLRs recognise pathogen-derived effector proteins and initiate effector-triggered immunity (ETI). However, the molecular mechanisms that link NLR-mediated effector recognition and downstream signalling are not fully understood. By exploiting the well-characterised tomato Prf/Pto NLR resistance complex, we identified the 14-3-3 proteins TFT1 and TFT3 as interacting partners of both the NLR complex and the protein kinase MAPKKKα. Moreover, we identified the helper NRC proteins (NLR-required for cell death) as integral components of the Prf /Pto NLR recognition complex. Notably our studies revealed that TFTs and NRCs interact with distinct modules of the NLR complex and, following effector recognition, dissociate facilitating downstream signalling. Thus, our data provide a mechanistic link between activation of immune receptors and initiation of downstream signalling cascades.
Item Type: | Journal Article | |||||||||||||||||||||||||||
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Subjects: | Q Science > QK Botany Q Science > QP Physiology Q Science > QR Microbiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Tomatoes -- Disease and pest resistance , Natural immunity , Nucleotides , Leucine , Molecular immunology , Plant cellular signal transduction | |||||||||||||||||||||||||||
Journal or Publication Title: | Nature Communications | |||||||||||||||||||||||||||
Publisher: | Nature Publishing Group UK | |||||||||||||||||||||||||||
ISSN: | 2041-1723 | |||||||||||||||||||||||||||
Official Date: | 4 May 2023 | |||||||||||||||||||||||||||
Dates: |
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Volume: | 14 | |||||||||||||||||||||||||||
Number: | 1 | |||||||||||||||||||||||||||
Article Number: | 2568 | |||||||||||||||||||||||||||
DOI: | 10.1038/s41467-023-38103-6 | |||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
Date of first compliant deposit: | 12 May 2023 | |||||||||||||||||||||||||||
Date of first compliant Open Access: | 12 May 2023 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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