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A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions
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Slack, Cathy, Somers, W. Gregory, Sousa-Nunes, Rita, Chia, William and Overton, Paul M. (2006) A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions. BMC Genetics, 7 (1). 33. doi:10.1186/1471-2156-7-33 ISSN 1471-2156.
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Official URL: http://doi.org/10.1186/1471-2156-7-33
Abstract
The asymmetric segregation of determinants during cell division is a fundamental mechanism for generating cell fate diversity during development. In Drosophila, neural precursors (neuroblasts) divide in a stem cell-like manner generating a larger apical neuroblast and a smaller basal ganglion mother cell. The cell fate determinant Prospero and its adapter protein Miranda are asymmetrically localized to the basal cortex of the dividing neuroblast and segregated into the GMC upon cytokinesis. Previous screens to identify components of the asymmetric division machinery have concentrated on embryonic phenotypes. However, such screens are reaching saturation and are limited in that the maternal contribution of many genes can mask the effects of zygotic loss of function, and other approaches will be necessary to identify further genes involved in neuroblast asymmetric division.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QH Natural history Q Science > QL Zoology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
Library of Congress Subject Headings (LCSH): | Drosophila, Molecular biology , Drosophila -- Physiological aspects, Cytokinesis | |||||||||
Journal or Publication Title: | BMC Genetics | |||||||||
Publisher: | BMC | |||||||||
ISSN: | 1471-2156 | |||||||||
Official Date: | 2 June 2006 | |||||||||
Dates: |
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Volume: | 7 | |||||||||
Number: | 1 | |||||||||
Article Number: | 33 | |||||||||
DOI: | 10.1186/1471-2156-7-33 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 18 May 2023 | |||||||||
Date of first compliant Open Access: | 18 May 2023 | |||||||||
RIOXX Funder/Project Grant: |
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