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Combining SNAPs with antibiotics shows enhanced synergistic efficacy against S. aureus and P. aeruginosa biofilms
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Garcia Maset, Ramón, Hapeshi, Alexia , Lapage, John, Harrington, Niamh, Littler, Jenny, Perrier, Sébastien and Harrison, Freya (2023) Combining SNAPs with antibiotics shows enhanced synergistic efficacy against S. aureus and P. aeruginosa biofilms. npj Biofilms and Microbiomes, 9 (1). 36. doi:10.1038/s41522-023-00401-8 ISSN 2055-5008.
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Official URL: http://dx.doi.org/10.1038/s41522-023-00401-8
Abstract
Biofilm infections are associated with a high mortality risk for patients. Antibiotics perform poorly against biofilm communities, so high doses and prolonged treatments are often used in clinical settings. We investigated the pairwise interactions of two synthetic nano-engineered antimicrobial polymers (SNAPs). The g-D50 copolymer was synergistic with penicillin and silver sulfadiazine against planktonic Staphylococcus aureus USA300 in synthetic wound fluid. Furthermore, the combination of g-D50 and silver sulfadiazine showed a potent synergistic antibiofilm activity against S. aureus USA300 using in vitro and ex vivo wound biofilm models. The a-T50 copolymer was synergistic with colistin against planktonic Pseudomonas aeruginosa in synthetic cystic fibrosis medium, and this pair showed a potent synergistic antibiofilm activity against P. aeruginosa in an ex vivo cystic fibrosis lung model. SNAPs thus have the potential for increased antibiofilm performance in combination with certain antibiotics to shorten prolonged treatments and reduce dosages against biofilm infection.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Science > Chemistry |
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Library of Congress Subject Headings (LCSH): | Biofilms, Antibiotics, Antimicrobial polymers, Staphylococcus aureus, Pseudomonas aeruginosa | |||||||||
Journal or Publication Title: | npj Biofilms and Microbiomes | |||||||||
Publisher: | Nature Publishing Group UK | |||||||||
ISSN: | 2055-5008 | |||||||||
Official Date: | 8 June 2023 | |||||||||
Dates: |
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Volume: | 9 | |||||||||
Number: | 1 | |||||||||
Article Number: | 36 | |||||||||
DOI: | 10.1038/s41522-023-00401-8 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 8 June 2023 | |||||||||
Date of first compliant Open Access: | 12 June 2023 | |||||||||
Funder: | Medical Research Council (Great Britain) (MRC) | |||||||||
Grant number: | MR/N014294/1 | |||||||||
RIOXX Funder/Project Grant: |
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