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Associations between the gut microbiome and metabolic, inflammatory and appetitive effects of sleeve gastrectomy
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Brown, H. N., Barber, Thomas M., Renshaw, D., Farnaud, S., Oduro-Donkor, D. and Turner, M. C. (2023) Associations between the gut microbiome and metabolic, inflammatory and appetitive effects of sleeve gastrectomy. Obesity Reviews, 24 (9). e13600. doi:10.1111/obr.13600 ISSN 1467-7881.
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Barber Obesity Reviews - 2023 - Brown gut microbiome pdf.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2133Kb) | Preview |
Official URL: https://doi.org/10.1111/obr.13600
Abstract
The complex and multifactorial etiology of obesity creates challenges for its effective long-term management. Increasingly, the gut microbiome is reported to play a key role in the maintenance of host health and wellbeing, with its dysregulation associated with chronic diseases such as obesity. The gut microbiome is hypothesized to contribute to obesity development and pathogenesis via several pathways involving food digestion, energy harvest and storage, production of metabolites influencing satiety, maintenance of gut barrier integrity, and bile acid metabolism. Moreover, the gut microbiome likely contributes to the metabolic, inflammatory, and satiety benefits and sustained weight-loss effects following bariatric procedures such as sleeve gastrectomy. While the field of gut microbiome research in relation to obesity and sleeve gastrectomy outcomes is largely in its infancy, the gut microbiome nonetheless holds great potential for understanding some of the mechanisms behind sleeve gastrectomy outcomes as well as for optimizing post-surgery benefits. This review will explore the current literature within the field as well as discuss the current limitations, including the small sample size, variability in methodological approaches, and lack of associative data, which need to be addressed in future studies.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Obesity Reviews | ||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||
| ISSN: | 1467-7881 | ||||||||
| Official Date: | September 2023 | ||||||||
| Dates: |
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| Volume: | 24 | ||||||||
| Number: | 9 | ||||||||
| Article Number: | e13600 | ||||||||
| DOI: | 10.1111/obr.13600 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 20 July 2023 | ||||||||
| Date of first compliant Open Access: | 20 July 2023 | ||||||||
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