The Library
Why do people take part in vaccine trials? A mixed methods narrative synthesis
Tools
Dean, Alex, Rose, Fi, Jones, Katherine, Scantlebury, Arabella, Adamson, Joy and Knapp, Peter (2023) Why do people take part in vaccine trials? A mixed methods narrative synthesis. Patient Education and Counseling, 114 . 107861. doi:10.1016/j.pec.2023.107861 ISSN 0738-3991.
|
PDF
1-s2.0-S0738399123002410-main.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (741Kb) | Preview |
Official URL: http://doi.org/10.1016/j.pec.2023.107861
Abstract
Objectives
To understand why individuals do or do not take part in vaccine trials, exploring the motivators and barriers to identify effective strategies to optimise recruitment in vaccine research.
Methods
Qualitative studies and quantitative surveys capturing data on reasons for trial participation/decline were included. Six databases were searched from 1996 to October 2021. Two reviewers independently screened and assessed risk of bias. Results were reported narratively and analysed using thematic analysis.
Results
We included 32 studies (17 qualitative; 12 quantitative; 3 mixed-methods) that covered a wide range of populations, geographical areas and disease types. Eight themes were identified 1) altruism; 2) potential for personal benefit; 3) perceived risks; 4) trust or distrust; 5) social networks; 6) stigma; 7) practical implications; 8) research vanguard.
Conclusion
Our findings provide a detailed description of how potential participants weigh up their decisions to participate in vaccine trials, which could inform the planning and implementation of studies to enhance recruitment.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Subjects: | R Medicine > R Medicine (General) | ||||||||
Library of Congress Subject Headings (LCSH): | Mixed methods research, Vaccines, Clinical trials, Decision making | ||||||||
Journal or Publication Title: | Patient Education and Counseling | ||||||||
Publisher: | Elsevier Ireland Ltd. | ||||||||
ISSN: | 0738-3991 | ||||||||
Official Date: | September 2023 | ||||||||
Dates: |
|
||||||||
Volume: | 114 | ||||||||
Article Number: | 107861 | ||||||||
DOI: | 10.1016/j.pec.2023.107861 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 26 June 2023 | ||||||||
Date of first compliant Open Access: | 26 June 2023 |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year