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Ultrafast spectroscopy of natural sunscreen filters
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Woolley, Jack Matthew (2020) Ultrafast spectroscopy of natural sunscreen filters. PhD thesis, University of Warwick.
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Official URL: http://webcat.warwick.ac.uk/record=b3913263
Abstract
Ultraviolet radiation (UVR) has both positive and negative effects on biological systems. In humans, for example, UVR is responsible for producing vitamin D, while excessive exposure to UVR increases the risk of skin cancer. To avoid photodamage, both plants and humans have developed molecular species to deal with any excessive UVR. Two such classes of molecular species in plants are mycosporine-like amino acids and sinapates. Both these species have previously been investigated for their ability to provide protection from UVR and they have been proposed to be the next generation of UV filters to be utilised in commercial sunscreen formulations. The work presented in this thesis builds on the current literature on both mycosporine-like amino acids and cinnamates, a family of molecules structurally similar to sinapates, and currently employed in commercial formulations. The work presented in Chapter 3 discusses the photodynamics of mycosporine-like amino acids motifs, the results of which are used to aid the discussion in Chapter 5 on the photodynamics of natural mycosporine-like amino acids themselves. Chapter 4 published work exploring the structure-dynamics-function relationship for a symmetrically functionalised methyl cinnamate. Again these results are utilised to further explore this relationship in Chapter 5 through additional functionalisation of the methyl cinnamate moiety. All of these experiments were performed on an ultrafast transient electronic absorption setup, the details of which are described in Chapter 2. By conducting studies aiming to understand the intrinsic molecular motions involved in photoprotection like those discussed in this thesis, it is hoped that we can then begin to utilise such structure-dynamics-function approaches to design next generation UV filters that are nature inspired.
Item Type: | Thesis (PhD) | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Ultraviolet radiation -- Physiological effect, Sunscreens (Cosmetics), Mycosporine-like amino acids, Photochemistry, Laser spectroscopy, Femtochemistry | ||||
Official Date: | July 2020 | ||||
Dates: |
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Institution: | University of Warwick | ||||
Theses Department: | Department of Chemistry | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Stavros, Vasilios G. | ||||
Format of File: | |||||
Extent: | xiii, 130 pages : illustrations (colour) | ||||
Language: | eng |
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