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Reduced cingulate gyrus volume in Cavalier King Charles Spaniels with syringomyelia and neuropathic pain revealed by voxel-based morphometry : a pilot study
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Nitzsche, Björn, Schulze, Sabine, Boltze, Johannes and Schmidt, Martin J. (2023) Reduced cingulate gyrus volume in Cavalier King Charles Spaniels with syringomyelia and neuropathic pain revealed by voxel-based morphometry : a pilot study. Frontiers in Neuroanatomy, 17 . 1175953. doi:10.3389/fnana.2023.1175953 ISSN 1662-5129.
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Official URL: https://doi.org/10.3389/fnana.2023.1175953
Abstract
Objective: Pathomorphological alterations of the central nervous system in dogs, such as syringomyelia and Chiari-like malformation, can cause cranial and cervical hyperesthesia and neuropathic pain. The long-term activity of the pain network can induce functional alteration and eventually even morphological changes in the pain network. This may happen especially in the prefrontal and cingulate cortex, where atrophy of the gray matter (GM) was observed in humans with chronic pain, irrespective of the nature of the pain syndrome. We tested the hypothesis that Cavalier King Charles Spaniels (CKCS) with Chiari-like malformation and associated syringomyelia (SM) and pain show cerebral morphological differences compared to animals without signs of syringomyelia and pain.
Methods: Volumetric datasets of 28 different brain structures were analyzed in a retrospective manner, including voxel-based morphometry, using magnetic resonance imaging data obtained from 41 dogs.
Results: Volumetric analyses revealed a decrease in GM volumes in the cingulate gyrus (CG) in CKCS with SM and chronic pain when normalized to brain volume. This finding was supported by voxel-based morphometry, which showed a cluster of significance within the CG.
Conclusion: GM atrophy in the CG is associated with chronic pain and thus may serve as an objective readout parameter for the diagnosis or treatment of canine pain syndromes.
Item Type: | Journal Article | ||||||
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Subjects: | S Agriculture > SF Animal culture | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Library of Congress Subject Headings (LCSH): | Cavalier King Charles spaniel, Syringomyelia, Arnold-Chiari deformity, Spinal cord -- Diseases, Dogs -- Diseases, Hyperalgesia, Pain in animals -- Treatment, Pet medicine | ||||||
Journal or Publication Title: | Frontiers in Neuroanatomy | ||||||
Publisher: | Frontiers Media | ||||||
ISSN: | 1662-5129 | ||||||
Official Date: | 17 July 2023 | ||||||
Dates: |
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Volume: | 17 | ||||||
Article Number: | 1175953 | ||||||
DOI: | 10.3389/fnana.2023.1175953 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 21 August 2023 | ||||||
Date of first compliant Open Access: | 22 August 2023 |
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