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Human protamines and male infertility
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UNSPECIFIED (1997) Human protamines and male infertility. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 14 (5). pp. 282-290. ISSN 1058-0468.
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Abstract
Purpose: Our purpose was to determine the ratio of protamine 1 to protamine 2 in human spermatozoa and relate it to in vitro fertilization rates (IVF) and standard semen parameters.
Methods: Couples who had been clinically diagnosed as having male-factor infertility and had undergone IVF treatment were grouped according to IVF rates and pregnancy outcome. Protamines were extracted and separated on acid urea polyacrylamide gels. The P1/P2 ratio correlation with semen parameters and IVF rates was investigated using nonparametric analysis.
Results: The P1/P2 ratio ranged from 0.55 to 1.29 in the control group of patients, who had fertilization rates greater than or equal to 50% and had achieved a pregnancy in one IVF cycle. Of the test patients with IVF < 50%, three (14%) had P1/P2 ratios outside the range exhibited by the control group and their sperm possessed large heads.
Conclusions: P1/P2 ratios were statistically negatively correlated with IVF rates in the control group and with progressive motile sperm concentration in the test group. We do not think that altered P1/P2 ratios are the primary cause of reduced fertilization.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH426 Genetics R Medicine > RG Gynecology and obstetrics |
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Journal or Publication Title: | JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | ||||
Publisher: | PLENUM PUBL CORP | ||||
ISSN: | 1058-0468 | ||||
Official Date: | May 1997 | ||||
Dates: |
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Volume: | 14 | ||||
Number: | 5 | ||||
Number of Pages: | 9 | ||||
Page Range: | pp. 282-290 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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