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Genomic based analysis of the biocontrol species Trichoderma harzianum : a model resource of structurally diverse pharmaceuticals and biopesticides
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Al-Salihi, Suhad A. A. and Alberti, Fabrizio (2023) Genomic based analysis of the biocontrol species Trichoderma harzianum : a model resource of structurally diverse pharmaceuticals and biopesticides. Journal of Fungi, 9 (9). 895. doi:10.3390/jof9090895 ISSN 2309-608X.
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WRAP-genomic-based-analysis-biocontrol-species-Trichoderma-harzianum-model-resource-structurally-diverse-pharmaceuticals-biopesticides-2023.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (4Mb) | Preview |
Official URL: https://doi.org/10.3390/jof9090895
Abstract
Fungi represents a rich repository of taxonomically restricted, yet chemically diverse, secondary metabolites that are synthesised via specific metabolic pathways. An enzyme’s specificity and biosynthetic gene clustering are the bottleneck of secondary metabolite evolution. Trichoderma harzianum M10 v1.0 produces many pharmaceutically important molecules; however, their specific biosynthetic pathways remain uncharacterised. Our genomic-based analysis of this species reveals the biosynthetic diversity of its specialised secondary metabolites, where over 50 BGCs were predicted, most of which were listed as polyketide-like compounds associated clusters. Gene annotation of the biosynthetic candidate genes predicted the production of many medically/industrially important compounds including enterobactin, gramicidin, lovastatin, HC-toxin, tyrocidine, equisetin, erythronolide, strobilurin, asperfuranone, cirtinine, protoilludene, germacrene, and epi-isozizaene. Revealing the biogenetic background of these natural molecules is a step forward towards the expansion of their chemical diversification via engineering their biosynthetic genes heterologously, and the identification of their role in the interaction between this fungus and its biotic/abiotic conditions as well as its role as bio-fungicide.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QK Botany S Agriculture > SB Plant culture |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Library of Congress Subject Headings (LCSH): | Natural pesticides, Biological pest control agents, Trichoderma -- Biotechnology, Metabolites | ||||||
Journal or Publication Title: | Journal of Fungi | ||||||
Publisher: | MDPI | ||||||
ISSN: | 2309-608X | ||||||
Official Date: | 31 August 2023 | ||||||
Dates: |
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Volume: | 9 | ||||||
Number: | 9 | ||||||
Article Number: | 895 | ||||||
DOI: | 10.3390/jof9090895 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 11 September 2023 | ||||||
Date of first compliant Open Access: | 11 September 2023 | ||||||
RIOXX Funder/Project Grant: |
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