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Use of atomic force microscopy in UVB-iced chromosome damage provides important bioinformation for cell damage assessment
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Wang, Bowei, Dong, Jianjun, Yang, Fan, Ju, Tuoyu, Li, Jiani, Wang, Junxi, Wang, Ying, Crabbe, M. James C., Tian, Yanling and Wang, Zuobin (2023) Use of atomic force microscopy in UVB-iced chromosome damage provides important bioinformation for cell damage assessment. Langmuir, 39 (37). pp. 13212-13221. doi:10.1021/acs.langmuir.3c01644 ISSN 1520-5827.
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Official URL: http://doi.org/10.1021/acs.langmuir.3c01644
Abstract
The chromosomal structure derived from UVB-stimulated HaCaT cells was detected by atomic force microscopy (AFM) to evaluate the effect of UVB irradiation. The results showed that the higher the UVB irradiation dose, the more the cells that had chromosome aberration. At the same time, different representative types of chromosome structural aberrations were investigated. We also revealed damage to both DNA and cells under the corresponding irradiation doses. It was found that the degree of DNA damage was directly proportional to the irradiation dose. The mechanical properties of cells were also changed after UVB irradiation, suggesting that cells experienced a series of chain reactions from inside to outside after irradiation. The high-resolution imaging of chromosome structures by AFM after UVB irradiation enables us to relate the damage between chromosomes, DNA, and cells caused by UVB irradiation and provides specific information on genetic effects.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Langmuir | ||||||||
Publisher: | American Chemical Society (ACS) | ||||||||
ISSN: | 1520-5827 | ||||||||
Official Date: | 19 September 2023 | ||||||||
Dates: |
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Volume: | 39 | ||||||||
Number: | 37 | ||||||||
Page Range: | pp. 13212-13221 | ||||||||
DOI: | 10.1021/acs.langmuir.3c01644 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | ** From Crossref journal articles via Jisc Publications Router ** History: epub 08-09-2023; issued 08-09-2023. | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Copyright Holders: | Copyright © 2023 American Chemical Society |
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