The Library
Structure of an H3N2 influenza virus nucleoprotein
Tools
Knight, Michael L., Fan, Haitian, Bauer, David L. V., Grimes, Jonathan M., Fodor, Ervin and Keown, Jeremy R. (2021) Structure of an H3N2 influenza virus nucleoprotein. Acta Crystallographica Section F Structural Biology Communications, 77 (7). pp. 208-214. doi:10.1107/S2053230X2100635X ISSN 2053-230X.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://doi.org/10.1107/S2053230X2100635X
Abstract
Influenza A viruses of the H1N1 and H3N2 subtypes are responsible for seasonal epidemic events. The influenza nucleoprotein (NP) binds to the viral genomic RNA and is essential for its replication. Efforts are under way to produce therapeutics and vaccines targeting the NP. Despite this, no structure of an NP from an H3N2 virus has previously been determined. Here, the structure of the A/Northern Territory/60/1968 (H3N2) influenza virus NP is presented at 2.2 Å resolution. The structure is highly similar to those of the A/WSN/1933 (H1N1) and A/Hong Kong/483/97 (H5N1) NPs. Nonconserved amino acids are widely dispersed both at the sequence and structural levels. A movement of the 73–90 RNA-binding loop is observed to be the key difference between the structure determined here and previous structures. The data presented here increase the understanding of structural conservation amongst influenza NPs and may aid in the design of universal interventions against influenza.
Item Type: | Journal Article | ||||||
---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Journal or Publication Title: | Acta Crystallographica Section F Structural Biology Communications | ||||||
Publisher: | International Union of Crystallography | ||||||
ISSN: | 2053-230X | ||||||
Official Date: | July 2021 | ||||||
Dates: |
|
||||||
Volume: | 77 | ||||||
Number: | 7 | ||||||
Page Range: | pp. 208-214 | ||||||
DOI: | 10.1107/S2053230X2100635X | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |