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A new flow-based design for double-lumen needles
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Cimpeanu, Radu, Castrejón-Pita, Alfonso A., Lim, Lee Nai, Vatish, Manu and Georgiou, Ektoras X. (2023) A new flow-based design for double-lumen needles. Journal of Biomechanics, 160 . 111832. doi:10.1016/j.jbiomech.2023.111832 ISSN 0021-9290.
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Official URL: https://doi.org/10.1016/j.jbiomech.2023.111832
Abstract
Oocyte retrieval forms a crucial part of in vitro fertilisation treatment and its ultimate outcome. Standard double-lumen needles, which include a sequence of aspiration and flushing steps, are characterised by a similar success rate to single-lumen needles, despite their increased cost. A novel hydrodynamics-based needle called the OxIVF needle is proposed here, which is geared towards the generation of an internal flow field within the full follicular volume via laterally, rather than frontally, oriented flushing, leading to successful retrievals with no additional stress on the oocyte. A two-dimensional digital twin of the follicular environment is created and tested via multi-phase flow direct numerical simulation. Oocyte initial location within the follicle is varied, while quantities of interest such as velocity magnitude and vorticity are measured with a high level of precision. This provides insight into the overall fluid motion, as well as the trajectory and stresses experienced by the oocyte. A comparative benchmark set of tests indicated a higher success rate of the OxIVF needle of up to 100%, marking a significant improvement over the traditional double-lumen design whose success rate of no more than 75% was also highly dependent on the location of the needle tip inside the follicle. All forces measured during these tests showcase how the oocyte experiences stresses which are no larger than at the aspiration point, with the flow field providing a gentle steering effect towards the extraction region. Finally, the flow generation strategy maximises oocyte yield, unlocking new capabilities in both human and veterinary contexts.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RG Gynecology and obstetrics | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | ||||||||
Library of Congress Subject Headings (LCSH): | Fertilization in vitro, Human, Fertilization in vitro, Human reproductive technology, Ovum, Human mechanics, Biomedical engineering | ||||||||
Journal or Publication Title: | Journal of Biomechanics | ||||||||
Publisher: | Pergamon Press | ||||||||
ISSN: | 0021-9290 | ||||||||
Official Date: | November 2023 | ||||||||
Dates: |
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Volume: | 160 | ||||||||
Article Number: | 111832 | ||||||||
DOI: | 10.1016/j.jbiomech.2023.111832 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 9 October 2023 | ||||||||
Date of first compliant Open Access: | 11 October 2023 | ||||||||
RIOXX Funder/Project Grant: |
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