The Library
Gender-specific clinical risk scores incorporating blood pressure variability for predicting incident dementia
Tools
Zhou, Jiandong, Lee, Sharen, Wong, Wing Tak, Waleed, Khalid Bin, Leung, Keith Sai Kit, Lee, Teddy Tai Loy, Wai, Abraham Ka Chung, Liu, Tong, Chang, Carlin, Cheung, Bernard Man Yung, Zhang, Qingpeng and Tse, Gary (2022) Gender-specific clinical risk scores incorporating blood pressure variability for predicting incident dementia. Journal of the American Medical Informatics Association, 29 (2). pp. 335-347. doi:10.1093/jamia/ocab173 ISSN 1527-974X.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1093/jamia/ocab173
Abstract
Introduction
The present study examined the gender-specific prognostic value of blood pressure (BP) and its variability in the prediction of dementia risk and developed a score system for risk stratification.
Materials and Methods
This was a retrospective, observational population-based cohort study of patients admitted to government-funded family medicine clinics in Hong Kong between January 1, 2000 and March 31, 2002 with at least 3 blood pressure measurements. Gender-specific risk scores for dementia were developed and tested.
Results
The study consisted of 74 855 patients, of whom 3550 patients (incidence rate: 4.74%) developed dementia over a median follow-up of 112 months (IQR= [59.8–168]). Nonlinear associations between diastolic/systolic BP measurements and the time to dementia presentation were identified. Gender-specific dichotomized clinical scores were developed for males (age, hypertension, diastolic and systolic BP and their measures of variability) and females (age, prior cardiovascular, respiratory, gastrointestinal diseases, diabetes mellitus, hypertension, stroke, mean corpuscular volume, monocyte, neutrophil, urea, creatinine, diastolic and systolic BP and their measures of variability). They showed high predictive strengths for both male (hazard ratio [HR]: 12.83, 95% confidence interval [CI]: 11.15–14.33, P value < .0001) and female patients (HR: 26.56, 95% CI: 14.44–32.86, P value < .0001). The constructed gender-specific scores outperformed the simplified systems without considering BP variability (C-statistic: 0.91 vs 0.82), demonstrating the importance of BP variability in dementia development.
Conclusion
Gender-specific clinical risk scores incorporating BP variability can accurately predict incident dementia and can be applied clinically for early disease detection and optimized patient management.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
Journal or Publication Title: | Journal of the American Medical Informatics Association | ||||||||
Publisher: | Oxford University Press | ||||||||
ISSN: | 1527-974X | ||||||||
Official Date: | February 2022 | ||||||||
Dates: |
|
||||||||
Volume: | 29 | ||||||||
Number: | 2 | ||||||||
Page Range: | pp. 335-347 | ||||||||
DOI: | 10.1093/jamia/ocab173 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |