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Supraglottic airway versus tracheal intubation for airway management in out-of-hospital cardiac arrest : a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials
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Forestell, Ben, Ramsden, Sophie, Sharif, Sameer, Centofanti, John, Al Lawati, Kumait, Fernando, Shannon M., Welsford, Michelle, Nichol, Graham, Nolan, Jerry P. and Rochwerg, Bram (2024) Supraglottic airway versus tracheal intubation for airway management in out-of-hospital cardiac arrest : a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials. Critical Care Medicine, 52 (2). e89-e99. doi:10.1097/ccm.0000000000006112 ISSN 0090-3493.
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Official URL: https://doi.org/10.1097/ccm.0000000000006112
Abstract
Objectives: Given the uncertainty regarding the optimal approach for airway management for adult patients with out-of-hospital cardiac arrest (OHCA), we conducted a systematic review and meta-analysis to compare the use of supraglottic airways (SGAs) with tracheal intubation for initial airway management in OHCA. Data Sources: We searched MEDLINE, PubMed, Embase, Cochrane Library, as well as unpublished sources, from inception to February 7, 2023. Study Selection: We included randomized controlled trials (RCTs) of adult OHCA patients randomized to SGA compared with tracheal intubation for initial prehospital airway management. Data Extraction: Reviewers screened abstracts, full texts, and extracted data independently and in duplicate. We pooled data using a random-effects model. We used the modified Cochrane risk of bias 2 tool and assessed certainty of evidence using the Grading Recommendations Assessment, Development, and Evaluation approach. We preregistered the protocol on PROSPERO (CRD42022342935). Data Synthesis: We included four RCTs (n = 13,412 patients). Compared with tracheal intubation , SGA use probably increases return of spontaneous circulation (ROSC) (relative risk [RR] 1.09; 95% CI, 1.02–1.15; moderate certainty) and leads to a faster time to airway placement (mean difference 2.5 min less; 95% CI, 1.6–3.4 min less; high certainty). SGA use may have no effect on survival at longest follow-up (RR 1.06; 95% CI, 0.84–1.34; low certainty), has an uncertain effect on survival with good functional outcome (RR 1.11; 95% CI, 0.82–1.50; very low certainty), and may have no effect on risk of aspiration (RR 1.04; 95% CI, 0.94 to 1.16; low certainty). Conclusions: In adult patients with OHCA, compared with tracheal intubation, the use of SGA for initial airway management probably leads to more ROSC, and faster time to airway placement, but may have no effect on longer-term survival outcomes or aspiration events.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||
Journal or Publication Title: | Critical Care Medicine | ||||||
Publisher: | Lippincott Williams & Wilkins | ||||||
ISSN: | 0090-3493 | ||||||
Official Date: | February 2024 | ||||||
Dates: |
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Volume: | 52 | ||||||
Number: | 2 | ||||||
Page Range: | e89-e99 | ||||||
DOI: | 10.1097/ccm.0000000000006112 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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