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The connectivity of the human frontal pole cortex, and a theory of its involvement in exploit versus explore
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Rolls, Edmund T., Deco, Gustavo, Huang, Chu-Chung and Feng, Jianfeng (2024) The connectivity of the human frontal pole cortex, and a theory of its involvement in exploit versus explore. Cerebral Cortex . doi:10.1093/cercor/bhad416 ISSN 1047-3211. (In Press)
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Official URL: https://doi.org/10.1093/cercor/bhad416
Abstract
The frontal pole is implicated in humans in whether to exploit resources versus explore alternatives. Effective connectivity, functional connectivity, and tractography were measured between six human frontal pole regions and for comparison 13 dorsolateral and dorsal prefrontal cortex regions, and the 360 cortical regions in the Human Connectome Project Multi-modal-parcellation atlas in 171 HCP participants. The frontal pole regions have effective connectivity with Dorsolateral Prefrontal Cortex regions, the Dorsal Prefrontal Cortex, both implicated in working memory; and with the orbitofrontal and anterior cingulate cortex reward/non-reward system. There is also connectivity with temporal lobe, inferior parietal, and posterior cingulate regions. Given this new connectivity evidence, and evidence from activations and damage, it is proposed that the frontal pole cortex contains autoassociation attractor networks that are normally stable in a short-term memory state, and maintain stability in the other prefrontal networks during stable exploitation of goals and strategies. However, if an input from the orbitofrontal or anterior cingulate cortex that expected reward, non-reward, or punishment is received, this destabilizes the frontal pole and thereby other prefrontal networks to enable exploration of competing alternative goals and strategies. The frontal pole connectivity with reward systems may be key in exploit versus explore.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Cerebral Cortex | ||||||||
Publisher: | Oxford University Press | ||||||||
ISSN: | 1047-3211 | ||||||||
Official Date: | January 2024 | ||||||||
Dates: |
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DOI: | 10.1093/cercor/bhad416 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | In Press | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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