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Physical activity and health-related quality of life of patients with chronic knee pain after total knee replacement : analysis of the PEP-TALK trial
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Fabiano, Gianluca, Smith, Toby O., Parsons, Scott, Ooms, Alexander, Dutton, Susan, Fordham, Beth, Hing, Caroline, Lamb, Sarah and Pinedo-Villanueva, Rafael (2024) Physical activity and health-related quality of life of patients with chronic knee pain after total knee replacement : analysis of the PEP-TALK trial. The Knee, 46 . pp. 80-88. doi:10.1016/j.knee.2023.11.012 ISSN 0968-0160.
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Official URL: https://doi.org/10.1016/j.knee.2023.11.012
Abstract
Background
Chronic pain is a major challenge for some people after total knee replacement (TKR). The changing impact of this complication during the first post-operative year remains unclear. This analysis aimed to examine how physical activity and health-related quality of life (HRQoL) evolved over the first year after TKR for patients with and without post-operative chronic knee pain.
Methods
We conducted a secondary analysis of data from a randomised controlled trial (PEP-TALK), which tested the effectiveness of a behaviour change physiotherapy intervention compared with usual rehabilitation after TKR. Mean UCLA Activity Score and EQ-5D-5L for participants with and without chronic knee pain (14 points or lower in the Oxford Knee Score Pain Subscale (OKS-PS) at six months post-TKR) were compared at six and 12 months post-TKR.
Results
Data from 83 participants were analysed. For those with chronic knee pain, UCLA Activity Score remained unchanged between baseline to six months (mean: 3.8 to 3.8), decreasing at 12 months (3.0). Those without post-operative chronic knee pain reported improved physical activity from baseline to six months (4.0 vs 4.9), plateauing at 12 months (4.9). Participants with chronic knee pain reported lower baseline HRQoL (0.28 vs 0.48). Both groups improved health utility over one year. Of those without chronic pain at six months, 8.5% returned to chronic pain by 12 months.
Conclusions
Monitoring clinical outcomes after six months may be indicated for those at risk of chronic pain post-TKR. Further, sufficiently powered analyses are warranted to increase the generalisability of this exploratory analyses’ results.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | The Knee | ||||||||
Publisher: | Elsevier | ||||||||
ISSN: | 0968-0160 | ||||||||
Official Date: | January 2024 | ||||||||
Dates: |
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Volume: | 46 | ||||||||
Page Range: | pp. 80-88 | ||||||||
DOI: | 10.1016/j.knee.2023.11.012 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 6 December 2023 | ||||||||
Date of first compliant Open Access: | 12 December 2023 | ||||||||
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