the environMENTAL Consortium (Including:
). (2023) Effects of urban living environments on mental health in adults. Nature Medicine, 29 (6). pp. 1456-1467. doi:10.1038/s41591-023-02365-w ISSN 1078-8956.Preview |
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Abstract
Urban-living individuals are exposed to many environmental factors that may combine and interact to influence mental health. While individual factors of an urban environment have been investigated in isolation, no attempt has been made to model how complex, real-life exposure to living in the city relates to brain and mental health, and how this is moderated by genetic factors. Using the data of 156,075 participants from the UK Biobank, we carried out sparse canonical correlation analyses to investigate the relationships between urban environments and psychiatric symptoms. We found an environmental profile of social deprivation, air pollution, street network and urban land-use density that was positively correlated with an affective symptom group (r = 0.22, Pperm < 0.001), mediated by brain volume differences consistent with reward processing, and moderated by genes enriched for stress response, including CRHR1, explaining 2.01% of the variance in brain volume differences. Protective factors such as greenness and generous destination accessibility were negatively correlated with an anxiety symptom group (r = 0.10, Pperm < 0.001), mediated by brain regions necessary for emotion regulation and moderated by EXD3, explaining 1.65% of the variance. The third urban environmental profile was correlated with an emotional instability symptom group (r = 0.03, Pperm < 0.001). Our findings suggest that different environmental profiles of urban living may influence specific psychiatric symptom groups through distinct neurobiological pathways.
| Item Type: | Journal Article |
|---|---|
| Subjects: | H Social Sciences > HT Communities. Classes. Races R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science |
| Library of Congress Subject Headings (LCSH): | Cities and towns, City planning, Mental health, Urban ecology (Sociology) |
| Journal or Publication Title: | Nature Medicine |
| Publisher: | Nature Publishing Group |
| ISSN: | 1078-8956 |
| Official Date: | June 2023 |
| Dates: | Date Event June 2023 Published 15 June 2023 Available 25 April 2023 Accepted |
| Volume: | 29 |
| Number: | 6 |
| Page Range: | pp. 1456-1467 |
| DOI: | 10.1038/s41591-023-02365-w |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 12 December 2023 |
| Date of first compliant Open Access: | 13 December 2023 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID 82150710554 [NSFC] National Natural Science Foundation of China 2018YFC1314301 National Basic Research Program of China (973 Program) Clinical Talent Training 123 Climbing Plan Tianjin Medical University 2022YFE0209400 National Basic Research Program of China (973 Program) Earth System Science Numerical Simulator Facility National Basic Research Program of China (973 Program) UNSPECIFIED American Friends of the Alexander von Humboldt Foundation |
| URI: | https://wrap.warwick.ac.uk/181701/ |
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