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Assessing reservoir host status in leishmaniasis with special reference to the infectiousness of Leishmania (Viannia) braziliensis infections in wild rodents
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Shaw, Jeffrey J., Marinho-Júnior, José F., Courtenay, Orin and Brandão-Filho, Sinval P. (2023) Assessing reservoir host status in leishmaniasis with special reference to the infectiousness of Leishmania (Viannia) braziliensis infections in wild rodents. Revista da Sociedade Brasileira de Medicina Tropical, 56 . e0503-2023. doi:10.1590/0037-8682-0503-2023 ISSN 1678-9849.
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Official URL: https://doi.org/10.1590/0037-8682-0503-2023
Abstract
Molecular methods have been responsible for a notable increase in the detection of Leishmaniinae infections in wild animals. Determining
their infectiousness is of paramount importance in evaluating their epidemiological significance. One of the most efficient ways of
determining infectiousness for vector borne diseases is xenodiagnosis with the appropriate vector. However, this is logistically very
difficult to accomplish in the field, and an ideal solution is to find a molecular surrogate for xenodiagnosis. In this review we discuss
different approaches to the problem by focusing on the infectiousness of Leishmania (Viannia) braziliensis in rodents under laboratory
and field conditions. Comparisons with similar studies for other Leishmania species emphasizes that there are pivotal differences in the
infectiousness and the importance of asymptomatic infections in different hosts. Potentially the most promising surrogate is the real time
quantitative PCR (qPCR). However, its success depends on choosing a tissue that relates to the vector’s feeding location and the parasite’s
tissue tropism. This requires detailed knowledge of the infection of each species in its wild hosts. We conclude that for L. (V.) braziliensis
infections in wild rodents the tissue of choice for a molecular xenodiagnostic test, based on the qPCR is blood, providing that a significant number of samples must be examined.
Item Type: | Journal Article | |||||||||||||||||||||||||||
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Subjects: | Q Science > QL Zoology Q Science > QR Microbiology R Medicine > RB Pathology R Medicine > RL Dermatology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Leishmaniasis, Cutaneous, Leishmaniasis, Cutaneous -- Molecular aspects, Xenodiagnosis , Leishmaniasis, Leishmaniasis -- Transmission , Rodents as carriers of disease | |||||||||||||||||||||||||||
Journal or Publication Title: | Revista da Sociedade Brasileira de Medicina Tropical | |||||||||||||||||||||||||||
Publisher: | FapUNIFESP (SciELO) | |||||||||||||||||||||||||||
ISSN: | 1678-9849 | |||||||||||||||||||||||||||
Official Date: | 15 December 2023 | |||||||||||||||||||||||||||
Dates: |
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Volume: | 56 | |||||||||||||||||||||||||||
Page Range: | e0503-2023 | |||||||||||||||||||||||||||
DOI: | 10.1590/0037-8682-0503-2023 | |||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
Date of first compliant deposit: | 5 January 2024 | |||||||||||||||||||||||||||
Date of first compliant Open Access: | 9 January 2024 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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