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Evidence synthesis and linkage for modelling the cost-effectiveness of diagnostic tests : preliminary good practice recommendations
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Shinkins, Bethany, Allen, A. Joy, Karichu, James, Garrison, Louis P. and Monz, Brigitta U. (2024) Evidence synthesis and linkage for modelling the cost-effectiveness of diagnostic tests : preliminary good practice recommendations. Applied Health Economics and Health Policy, 22 (2). pp. 131-144. doi:10.1007/s40258-023-00855-z ISSN 1179-1896.
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Official URL: http://doi.org/10.1007/s40258-023-00855-z
Abstract
Objectives: To develop preliminary good practice recommendations for synthesising and linking evidence of treatment effectiveness when modelling the cost-effectiveness of diagnostic tests. Methods: We conducted a targeted review of guidance from key Health Technology Assessment (HTA) bodies to summarise current recommendations on synthesis and linkage of treatment effectiveness evidence within economic evaluations of diagnostic tests. We then focused on a specific case study, the cost-effectiveness of troponin for the diagnosis of myocardial infarction, and reviewed the approach taken to synthesise and link treatment effectiveness evidence in different modelling studies. Results: The Australian and UK HTA bodies provided advice for synthesising and linking treatment effectiveness in diagnostic models, acknowledging that linking test results to treatment options and their outcomes is common. Across all reviewed models for the case study, uniform test-directed treatment decision making was assumed, i.e., all those who tested positive were treated. Treatment outcome data from a variety of sources, including expert opinion, were utilised for linked clinical outcomes. Preliminary good practice recommendations for data identification, integration and description are proposed. Conclusion: Modelling the cost-effectiveness of diagnostic tests poses unique challenges in linking evidence on test accuracy to treatment effectiveness data to understand how a test impacts patient outcomes and costs. Upfront consideration of how a test and its results will likely be incorporated into patient diagnostic pathways is key to exploring the optimal design of such models. We propose some preliminary good practice recommendations to improve the quality of cost-effectiveness evaluations of diagnostics tests going forward.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||
Library of Congress Subject Headings (LCSH): | Medical technology -- Cost effectiveness, Clinical medicine -- Decision making, Evidence-based medicine, Troponin I -- Cost effectiveness, Myocardial infarction -- Diagnosis , Function tests (Medicine) -- Cost effectiveness | ||||||
Journal or Publication Title: | Applied Health Economics and Health Policy | ||||||
Publisher: | Springer International Publishing | ||||||
ISSN: | 1179-1896 | ||||||
Official Date: | March 2024 | ||||||
Dates: |
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Volume: | 22 | ||||||
Number: | 2 | ||||||
Page Range: | pp. 131-144 | ||||||
DOI: | 10.1007/s40258-023-00855-z | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 12 March 2024 | ||||||
Date of first compliant Open Access: | 15 March 2024 | ||||||
RIOXX Funder/Project Grant: |
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