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pH-Responsive amphiphilic triblock fluoropolymers as assemble oxygen nanoshuttles for enhancing PDT against hypoxic tumor
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Zhang, Jun-an, Haddleton, David M., Wilson, Paul, Zhu, Lin-hua, Dai, Chun-yan and Zhao, Lin-lu (2024) pH-Responsive amphiphilic triblock fluoropolymers as assemble oxygen nanoshuttles for enhancing PDT against hypoxic tumor. Bioconjugate Chemistry, 35 (3). pp. 400-411. doi:10.1021/acs.bioconjchem.4c00029 ISSN 1043-1802.
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WRAP-pH-Responsive-amphiphilic-triblock-fluoropolymers-assemble-oxygen-nanoshuttles-enhancing-PDT-against-hypoxic-tumor-2024.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 17 February 2025. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Download (1719Kb) |
Official URL: https://doi.org/10.1021/acs.bioconjchem.4c00029
Abstract
Photodynamic therapy (PDT) is a cancer treatment strategy that utilizes photosensitizers to convert oxygen within tumors into reactive singlet oxygen (1O2) to lyse tumor cells. Nevertheless, pre-existing tumor hypoxia and oxygen consumption during PDT can lead to an insufficient oxygen supply, potentially reducing the photodynamic efficacy. In response to this issue, we have devised a pH-responsive amphiphilic triblock fluorinated polymer (PDP) using copper-mediated RDRP. This polymer, composed of poly(ethylene glycol) methyl ether acrylate, 2-(diethylamino)ethyl methacrylate, and (perfluorooctyl)ethyl acrylate, self-assembles in an aqueous environment. Oxygen, chlorine e6 (Ce6), and doxorubicin (DOX) can be codelivered efficiently by PDP. The incorporation of perfluorocarbon into the formulation enhances the oxygen-carrying capacity of PDP, consequently extending the lifetime of 1O2. This increased lifetime, in turn, amplifies the PDT effect and escalates the cellular cytotoxicity. Compared with PDT alone, PDP@Ce6-DOX-O2 NPs demonstrated significant inhibition of tumor growth. This study proposes a novel strategy for enhancing the efficacy of PDT.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Bioconjugate Chemistry | ||||||||
Publisher: | American Chemical Society | ||||||||
ISSN: | 1043-1802 | ||||||||
Official Date: | 20 March 2024 | ||||||||
Dates: |
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Volume: | 35 | ||||||||
Number: | 3 | ||||||||
Page Range: | pp. 400-411 | ||||||||
DOI: | 10.1021/acs.bioconjchem.4c00029 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Re-use Statement: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Bioconjugate Chemistry, Copyright © 2024 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.bioconjchem.4c00029 | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 11 April 2024 |
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