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Decoding lifespan secrets : the role of the gonad in C. elegans aging
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Pires-daSilva, Andre, Kelleher, Rhianne and Reynoldson, Luke (2024) Decoding lifespan secrets : the role of the gonad in C. elegans aging. Frontiers in Aging Neuroscience, 5 . 1380016. doi:10.3389/fragi.2024.1380016 ISSN 1663-4365.
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Official URL: http://doi.org/10.3389/fragi.2024.1380016
Abstract
The gonad has become a central organ for understanding aging in C. elegans, as removing the proliferating stem cells in the germline results in significant lifespan extension.Similarly, when starvation in late larval stages leads to the quiescence of germline stem cells the adult nematode enters reproductive diapause, associated with an extended lifespan. This review summarizes recent advancements in identifying the mechanisms behind gonadmediated lifespan extension, including comparisons with other nematodes and the role of lipid signaling and transcriptional changes. Given that the gonad also mediates lifespan regulation in other invertebrates and vertebrates, elucidating the underlying mechanisms may help to gain new insights into the mechanisms and evolution of aging.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Journal or Publication Title: | Frontiers in Aging Neuroscience | ||||||
Publisher: | Frontiers Research Foundation | ||||||
ISSN: | 1663-4365 | ||||||
Official Date: | 26 March 2024 | ||||||
Dates: |
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Volume: | 5 | ||||||
Article Number: | 1380016 | ||||||
DOI: | 10.3389/fragi.2024.1380016 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 19 March 2024 | ||||||
Date of first compliant Open Access: | 26 March 2024 |
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