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Malignancy‐associated ischemic stroke : implications for diagnostic and therapeutic workup
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Xie, Wanqing, Hsu, Szuyao, Lin, Yuxuan, Xie, Lv, Jin, Xia, Zhu, Ziyu, Guo, Yunlu, Chen, Caiyang, Huang, Dan, Boltze, Johannes and Li, Peiying (2024) Malignancy‐associated ischemic stroke : implications for diagnostic and therapeutic workup. CNS Neuroscience & Therapeutics, 30 (3). e14619. doi:10.1111/cns.14619 ISSN 1755-5930.
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WRAP-malignancy‐associated-ischemic-stroke-implications-diagnostic-therapeutic-workup-2024.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1590Kb) | Preview |
Official URL: http://dx.doi.org/10.1111/cns.14619
Abstract
Background:
Patients with malignancies have an increased risk of suffering ischemic stroke via several mechanisms such as coagulation dysfunction and other malignancy-related effects as well as iatrogenic causes. Moreover, stroke can be the first sign of an occult malignancy, termed as malignancy-associated ischemic stroke (MAS). Therefore, timely diagnostic assessment and targeted management of this complex clinical situation are critical.
Findings:
Patients with both stroke and malignancy have atypical ages, risk factors, and often exhibit malignancy-related symptoms and multiple lesions on neuroimaging. New biomarkers such as eicosapentaenoic acid and blood mRNA profiles may help in distinguishing MAS from other strokes. In terms of treatment, malignancy should not be considered a contraindication, given comparable rates of recanalization and complications between stroke patients with or without malignancies.
Conclusion:
In this review, we summarize the latest developments in diagnosing and managing MAS, especially stroke with occult malignancies, and provide new recommendations from recently emerged clinical evidence for diagnostic and therapeutic workup strategies.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||||||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Cerebral ischemia -- Diagnosis, Cerebral ischemia -- Treatment, Cerebrovascular disease -- Treatment, Anticoagulants (Medicine), Anticoagulants (Medicine) -- Therapeutic use, Cerebrovascular disease -- Chemotherapy | ||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | CNS Neuroscience & Therapeutics | ||||||||||||||||||||||||||||||||||||
Publisher: | Wiley | ||||||||||||||||||||||||||||||||||||
ISSN: | 1755-5930 | ||||||||||||||||||||||||||||||||||||
Official Date: | March 2024 | ||||||||||||||||||||||||||||||||||||
Dates: |
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Volume: | 30 | ||||||||||||||||||||||||||||||||||||
Number: | 3 | ||||||||||||||||||||||||||||||||||||
Article Number: | e14619 | ||||||||||||||||||||||||||||||||||||
DOI: | 10.1111/cns.14619 | ||||||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 27 March 2024 | ||||||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 2 April 2024 | ||||||||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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