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Epistasis, core-genome disharmony, and adaptation in recombining bacteria
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(2024) Epistasis, core-genome disharmony, and adaptation in recombining bacteria. mBio . e00581-24. doi:10.1128/mbio.00581-24 ISSN 2150-7511. (In Press)
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taylor-et-al-2024-epistasis-core-genome-disharmony-and-adaptation-in-recombining-bacteria.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1551Kb) | Preview |
Official URL: http://doi.org/10.1128/mbio.00581-24
Abstract
Recombination of short DNA fragments via horizontal gene transfer (HGT) can introduce beneficial alleles, create genomic disharmony through negative epistasis, and create adaptive gene combinations through positive epistasis. For non-core (accessory) genes, the negative epistatic cost is likely to be minimal because the incoming genes have not co-evolved with the recipient genome and are frequently observed as tightly linked cassettes with major effects. By contrast, interspecific recombination in the core genome is expected to be rare because disruptive allelic replacement is likely to introduce negative epistasis. Why then is homologous recombination common in the core of bacterial genomes? To understand this enigma, we take advantage of an exceptional model system, the common enteric pathogens Campylobacter jejuni and C. coli that are known for very high magnitude interspecies gene flow in the core genome. As expected, HGT does indeed disrupt co-adapted allele pairings, indirect evidence of negative epistasis. However, multiple HGT events enable recovery of the genome’s co-adaption between introgressing alleles, even in core metabolism genes (e.g., formate dehydrogenase). These findings demonstrate that, even for complex traits, genetic coalitions can be decoupled, transferred, and independently reinstated in a new genetic background—facilitating transition between fitness peaks. In this example, the two-step recombinational process is associated with C. coli that are adapted to the agricultural niche.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | Q Science > QH Natural history > QH426 Genetics | ||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Genetic transformation, Genetic recombination, Campylobacter, Hybridization | ||||||||||||||||||
Journal or Publication Title: | mBio | ||||||||||||||||||
Publisher: | American Society for Microbiology | ||||||||||||||||||
ISSN: | 2150-7511 | ||||||||||||||||||
Official Date: | 2024 | ||||||||||||||||||
Dates: |
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Article Number: | e00581-24 | ||||||||||||||||||
DOI: | 10.1128/mbio.00581-24 | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | In Press | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Copyright Holders: | © 2024 Taylor et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. | ||||||||||||||||||
Date of first compliant deposit: | 2 May 2024 | ||||||||||||||||||
Date of first compliant Open Access: | 3 May 2024 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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