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The human homolog T of the mouse T(Brachyury) gene: Gene structure, cDNA sequence, and assignment to chromosome 6q27
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UNSPECIFIED (1996) The human homolog T of the mouse T(Brachyury) gene: Gene structure, cDNA sequence, and assignment to chromosome 6q27. GENOME RESEARCH, 6 (3). pp. 226-233.
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Abstract
We have cloned the human gene encoding the transcription factor T. T protein is vital for the formation of posterior mesoderm and axial development in all vertebrates. Brachyury mutant mice, which lack T protein, die in utero With abnormal notochord, posterior somites, and allantois. We have identified human T genomic clones and derived the mRNA sequence and gene structure. There is 91% amino acid identity between human and mouse T proteins overall and complete identity across 77 amino acids of the T-box motif within the DNA-binding domain. Human T expression is very similar to that found for T in other vertebrate species and is confined to cells derived From the notochord. The human T gene maps to chromosome 6q27 and is only the second human member of the T-box gene Family to be described.
Item Type: | Journal Item | ||||
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Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology Q Science > QH Natural history > QH426 Genetics |
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Journal or Publication Title: | GENOME RESEARCH | ||||
Publisher: | COLD SPRING HARBOR LAB PRESS | ||||
ISSN: | 1054-9803 | ||||
Official Date: | March 1996 | ||||
Dates: |
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Volume: | 6 | ||||
Number: | 3 | ||||
Number of Pages: | 8 | ||||
Page Range: | pp. 226-233 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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