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A STUDY OF THE INTERACTIONS BETWEEN GROUP-1 METALS AND THE C-TERMINUS OF PEPTIDES BY MEANS OF HIGH-ENERGY TANDEM MASS-SPECTROMETRY
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UNSPECIFIED (1995) A STUDY OF THE INTERACTIONS BETWEEN GROUP-1 METALS AND THE C-TERMINUS OF PEPTIDES BY MEANS OF HIGH-ENERGY TANDEM MASS-SPECTROMETRY. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 117 (40). pp. 10093-10097. ISSN 0002-7863.
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Abstract
Alkali metal-peptide complexes of the type (M - H + 2Cat)(+) have been studied by high energy collision-induced dissociation. In addition to structure specific sequence ions, loss of the C-terminal functional group as a radical ion occurs as a prominent fragmentation channel. C-terminal acids generate (Cat(2)CO(2))(.+) and (Cat(2))(.+) in a fashion similar to the behavior of fatty acids. C-terminal amides generate (Cat(2)NCO)(+) and (Cat(2))(.+) which have not been previously discussed. The formation of all of these may be rationalized by a series of consecutive radical reactions. During these fragmentations the sites of metal ion binding are well defined and equally suitable for the attachment of both small and large univalent group 1 metals. Mixed cation systems of the general form (M - H + Cat(A) + Cat(B))(+) also generate these radical ion species. The binding of two distinct cations to the same peptide allows one to investigate certain competitive loss processes.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Journal or Publication Title: | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | ||||
Publisher: | AMER CHEMICAL SOC | ||||
ISSN: | 0002-7863 | ||||
Official Date: | 11 October 1995 | ||||
Dates: |
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Volume: | 117 | ||||
Number: | 40 | ||||
Number of Pages: | 5 | ||||
Page Range: | pp. 10093-10097 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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