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ANALYSIS OF PYRIDINOLINE AND ITS DERIVATIVES BY SCANNING-ARRAY 4-SECTOR TANDEM MASS-SPECTROMETRY
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UNSPECIFIED (1994) ANALYSIS OF PYRIDINOLINE AND ITS DERIVATIVES BY SCANNING-ARRAY 4-SECTOR TANDEM MASS-SPECTROMETRY. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 8 (1). pp. 99-104. ISSN 0951-4198.
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Abstract
Structures of the trifunctional crosslink molecules, pyridinoline, deoxypyridinoline and glucosylgalactosyl-pyridinoline, have been characterized by positive-ion liquid secondary-ion mass spectrometry (LSIMS) and collision-induced dissociation with scanning-array four-sector tandem mass spectrometry. It has been found that: (i) the naturally occurring cations (Cat+) are readily desorbed by positive-ion LSIMS utilizing glycerol + thioglycerol (1:1) as liquid matrix and dominate the spectra, facilitating accurate mass measurement; (ii) changing the matrix to 3-nitrobenzyl alcohol leaves little evidence of the cation, and (iii) collision-induced dissociation of the cations (Cat+) of pyridinoline, deoxypyridinoline and glucosylgalactosyl-pyridinoline gives a wealth of fragmentation for structure elucidation. These fundamental studies of tandem mass spectra of the known trifunctional crosslink molecules provided valuable structure-related information, which help in the identification of the tissue-specific peptides containing these crosslinks. Artefact ions in these tandem mass spectra are remarkably abundant.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry Q Science > QC Physics |
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Journal or Publication Title: | RAPID COMMUNICATIONS IN MASS SPECTROMETRY | ||||
Publisher: | JOHN WILEY & SONS LTD | ||||
ISSN: | 0951-4198 | ||||
Official Date: | January 1994 | ||||
Dates: |
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Volume: | 8 | ||||
Number: | 1 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 99-104 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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