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The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya
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Ochola, Rachel, Sande, Charles, Fegan, Greg, Scott, P. D. (Paul D.), Medley, Graham, Cane, Patricia and Nokes, D. James (2009) The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya. PLoS One, Vol.4 (No.12). e8088. doi:10.1371/journal.pone.0008088 ISSN 1932-6203.
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Official URL: http://dx.doi.org/10.1371/journal.pone.0008088
Abstract
Background
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in infants. The rate of decay of RSV-specific maternal antibodies (RSV-matAb), the factors affecting cord blood levels, and the relationship between these levels and protection from infection are poorly defined.
Methods
A birth cohort (n = 635) in rural Kenya, was studied intensively to monitor infections and describe age-related serological characteristics. RSV specific IgG antibody (Ab) in serum was measured by the enzyme linked immunosorbent assay (ELISA) in cord blood, consecutive samples taken 3 monthly, and in paired acute and convalescent samples. A linear regression model was used to calculate the rate of RSV-matAb decline. The effect of risk factors on cord blood titres was investigated.
Results
The half-life of matAb in the Kenyan cohort was calculated to be 79 days (95% confidence limits (CL): 76–81 days). Ninety seven percent of infants were born with RSV-matAb. Infants who subsequently experienced an infection in early life had significantly lower cord titres of anti-RSV Ab in comparison to infants who did not have any incident infection in the first 6 months (P = 0.011). RSV infections were shown to have no effect on the rate of decay of RSV-matAb.
Conclusion
Maternal-specific RSV Ab decline rapidly following birth. However, we provide evidence of protection against severe disease by RSV-matAb during the first 6–7 months. This suggests that boosting maternal-specific Ab by RSV vaccination may be a useful strategy to consider.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
Library of Congress Subject Headings (LCSH): | Respiratory syncytial virus -- Kenya -- Kilifi District, Immunoglobulin G, Maternally acquired immunity -- Kenya -- Kilifi District, Communicable diseases -- Prevention, Enzyme-linked immunosorbent assay, Vaccination | ||||
Journal or Publication Title: | PLoS One | ||||
Publisher: | Public Library of Science | ||||
ISSN: | 1932-6203 | ||||
Official Date: | 2 December 2009 | ||||
Dates: |
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Volume: | Vol.4 | ||||
Number: | No.12 | ||||
Page Range: | e8088 | ||||
DOI: | 10.1371/journal.pone.0008088 | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Wellcome Trust (London, England) | ||||
Grant number: | 061584 (WT), 076278 (WT) |
Data sourced from Thomson Reuters' Web of Knowledge
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