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Insights into neutralization of animal viruses gained from study of influenza virus
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Outlaw, Mark C. and Dimmock, N. J. (1991) Insights into neutralization of animal viruses gained from study of influenza virus. Epidemiology and Infection, Vol.106 (No.2). pp. 205-220. doi:10.1017/S0950268800048354 ISSN 0950-2688.
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Official URL: http://dx.doi.org/10.1017/S0950268800048354
Abstract
It has long been known that the binding of antibodies to viruses can result in a loss of infectivity, or neutralization, but little is understood of the mechanism or mechanisms of this process. This is probably because neutralization is a multifactorial phenomenon depending upon the nature of the virus itself, the particular antigenic site involved, the isotype of immunoglobulin and the ratio of virus to immunoglobulin (see below). Thus not only is it likely that neutralization of one virus will differ from another but that changing the circumstances of neutralization can change the mechanism itself. To give coherence to the topic we are concentrating this review on one virus, influenza type A which is itself well studied and reasonably well understood [1–3]. Reviews of the older literature can be found in references 4 to 7.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | S Agriculture > SF Animal culture Q Science > QR Microbiology > QR355 Virology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
| Library of Congress Subject Headings (LCSH): | Influenza viruses -- Research, Viral antibodies -- Research, Virus diseases -- Immunological aspects, Veterinary virology | ||||
| Journal or Publication Title: | Epidemiology and Infection | ||||
| Publisher: | Cambridge University Press | ||||
| ISSN: | 0950-2688 | ||||
| Official Date: | April 1991 | ||||
| Dates: |
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| Volume: | Vol.106 | ||||
| Number: | No.2 | ||||
| Page Range: | pp. 205-220 | ||||
| DOI: | 10.1017/S0950268800048354 | ||||
| Status: | Peer Reviewed | ||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||
| Funder: | Science and Engineering Research Council (Great Britain) (SERC), Wellcome Trust (London, England), Great Britain. Ministry of Defence (MoD) |
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