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Rev: beyond nuclear export
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Groom, Harriet C. T., Anderson, Emma C. and Lever, Andrew M. L. (2009) Rev: beyond nuclear export. Journal of General Virology, Vol.90 (Part 6). pp. 1303-1318. doi:10.1099/vir.0.011460-0
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Official URL: http://dx.doi.org/10.1099/vir.0.011460-0
Abstract
Rev remains a hot topic. In this review, we revisit the insights that have been gained into the control of gene expression by the retroviral protein Rev and speculate on where current research is leading. We outline what is known about the role of Rev in translation and encapsidation and how these are linked to its more traditional role of nuclear export, underlining the multifaceted nature of this small viral protein. We discuss what more is to be learned in these fields and why continuing research on these 116 amino acids and understanding their function is still important in devising methods to combat AIDS.
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Subjects: | T Technology > TP Chemical technology Q Science > QR Microbiology > QR355 Virology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
| Journal or Publication Title: | Journal of General Virology | ||||
| Publisher: | Society for General Microbiology | ||||
| ISSN: | 0022-1317 | ||||
| Official Date: | June 2009 | ||||
| Dates: |
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| Volume: | Vol.90 | ||||
| Number: | Part 6 | ||||
| Number of Pages: | 16 | ||||
| Page Range: | pp. 1303-1318 | ||||
| DOI: | 10.1099/vir.0.011460-0 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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