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Dicarbonyls linked to damage in the powerhouse : glycation of mitochondrial proteins and oxidative stress
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Rabbani, Naila and Thornalley, Paul J. (2008) Dicarbonyls linked to damage in the powerhouse : glycation of mitochondrial proteins and oxidative stress. In: 3rd Intracellular Proteolysis Meeting, Canary Isl, Spain, Mar 05-07, 2008. Published in: Biochemical Society Transactions, Vol.36 (Pt.5). pp. 1045-1050. doi:10.1042/BST0361045 ISSN 0300-5127.
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Official URL: http://dx.doi.org/10.1042/BST0361045
Abstract
Protection of mitochondrial proteins from glycation by endogenous dicarbonyl compounds, methylglyoxal and glyoxal, was found recently to prevent increased formation of reactive oxygen species and oxidative and nitrosative damage to the proteome during aging and produce life extension in the nematode Caenorhabditis elegans. This suggests that dicarbonyl glycation damage to the mitochondrial proteome may be a preceding event to mitochondrial dysfunction leading to oxidative stress. Future research will address the functional charges in mitochondrial proteins that are the targets for dicarbonyl glycation.
| Item Type: | Conference Item (Paper) | ||||
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| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Oxidative stress, Mitochondria, Glycosylation | ||||
| Journal or Publication Title: | Biochemical Society Transactions | ||||
| Publisher: | Portland Press Ltd | ||||
| ISSN: | 0300-5127 | ||||
| Official Date: | October 2008 | ||||
| Dates: |
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| Volume: | Vol.36 | ||||
| Number: | Pt.5 | ||||
| Number of Pages: | 6 | ||||
| Page Range: | pp. 1045-1050 | ||||
| DOI: | 10.1042/BST0361045 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Wellcome Trust (London, England), British Heart Foundation, Diabetes UK, Cancer Research UK, British Council, Sixth Framework Programme (European Commission) (FP6) | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 3rd Intracellular Proteolysis Meeting | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Canary Isl, Spain | ||||
| Date(s) of Event: | Mar 05-07, 2008 |
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