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The colocalization transition of homologous chromosomes at meiosis
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Nicodemi, Mario, Panning, Barbara and Prisco, Antonella (2008) The colocalization transition of homologous chromosomes at meiosis. Physical Review E, Vol.77 (No.6 Part 1). doi:10.1103/PhysRevE.77.061913 ISSN 1539-3755.
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Official URL: http://dx.doi.org/10.1103/PhysRevE.77.061913
Abstract
Meiosis is the specialized cell division required in sexual reproduction. During its early stages, in the mother cell nucleus, homologous chromosomes recognize each other and colocalize in a crucial step that remains one of the most mysterious of meiosis. Starting from recent discoveries on the system molecular components and interactions, we discuss a statistical mechanics model of chromosome early pairing. Binding molecules mediate long-distance interaction of special DNA recognition sequences and, if their concentration exceeds a critical threshold, they induce a spontaneous colocalization transition of chromosomes, otherwise independently diffusing.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QC Physics Q Science > QH Natural history > QH301 Biology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||
Library of Congress Subject Headings (LCSH): | Fluorescence microscopy, Homology (Biology), Chromosomes, Meiosis, Statistical mechanics | ||||
Journal or Publication Title: | Physical Review E | ||||
Publisher: | American Physical Society | ||||
ISSN: | 1539-3755 | ||||
Official Date: | June 2008 | ||||
Dates: |
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Volume: | Vol.77 | ||||
Number: | No.6 Part 1 | ||||
Number of Pages: | 4 | ||||
DOI: | 10.1103/PhysRevE.77.061913 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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