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Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitro
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Ahmed, Usman, Dobler, Darin, Larkin, Sarah J., Rabbani, Naila and Thornalley, Paul J. (2008) Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitro. In: 9th International Symposium on the Maillard Reaction, Munich, Germany, Sep, 2007. Published in: New York Academy of Sciences. Annals, Vol.1126 pp. 262-264. ISBN 978-1-57331-719-1. doi:10.1196/annals.1433.035 ISSN 0077-8923.
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Official URL: http://dx.doi.org/10.1196/annals.1433.035
Abstract
Dicarbonyl glycation of RGD and GFOGER sites in type IV collagen has been associated with decreased angiogenesis. In this study, we investigated whether overexpression of glyoxalase 1 to decrease dicarbonyl glycation would prevent the angiogenesis deficit induced by hyperglycemia in vitro. Transfection of human microvascular endothelial cells resulted in a four-fold increase in glyoxalase 1 activity compared with controls. Incubation of human microvascular endothelial cells in model hyperglycemia produced a 32% decrease in formation of tube structures that was prevented by glyoxalase 1 overexpression. We conclude that increased protection against dicarbonyl glycation of endothelial cell protein protects hyperglycemia-induced angiogenesis deficit.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Glyoxalase, Neovascularization, Endothelial cells, Diabetes, Glycosylation | ||||
| Series Name: | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | ||||
| Journal or Publication Title: | New York Academy of Sciences. Annals | ||||
| Publisher: | Wiley-Blackwell Publishing, Inc. | ||||
| ISBN: | 978-1-57331-719-1 | ||||
| ISSN: | 0077-8923 | ||||
| Editor: | Schleicher, E and Somoza, V and Shieberle, P | ||||
| Official Date: | April 2008 | ||||
| Dates: |
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| Volume: | Vol.1126 | ||||
| Number of Pages: | 3 | ||||
| Page Range: | pp. 262-264 | ||||
| DOI: | 10.1196/annals.1433.035 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Wellcome Trust (London, England), Cancer Research UK | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 9th International Symposium on the Maillard Reaction | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Munich, Germany | ||||
| Date(s) of Event: | Sep, 2007 |
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