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Seroepidemiology of group A rotavirus in suburban São Paulo, Brazil
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Cox, M. J., Azevedo, R. S., Nokes, D. James, Beards, G. M., McCrae, Malcolm A., Massad, Eduardo and Medley, Graham (1998) Seroepidemiology of group A rotavirus in suburban São Paulo, Brazil. Epidemiology and Infection, Vol.120 . pp. 327-334. doi:10.1017/S0950268898008759 ISSN 0950-2688.
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Official URL: http://dx.doi.org/10.1017/S0950268898008759
Abstract
Age-specifc patterns of rotavirus infection were investigated using a randomly selected and
representative sample of sera from a suburban community of São Paulo, Brazil screened for
class-specifc antibodies to group A rotavirus. Age-serology of anti-rotavirus IgG showed
primary infection predominant in young infants with a median age of around 18 months
consistent with IgM serology suggesting highest rates of recent infection between ages 4 and 48
months. Anti-rotavirus serum IgA prevalence increased gradually with age. Paired samples
from infants, collected 1 month apart, indicated high exposure rates with seroconversion
occurring in several infants during the reported low transmission season. Between 5 and 10%
of adults had elevated IgM levels indicative of recent infection and, potentially, of an
important contribution adults may play to rotavirus transmission. Further understanding of the
dynamics of rotavirus transmission within populations, at group and serotype level, would
benefit the design and monitoring of future immunization programmes.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology > QR355 Virology | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
| Library of Congress Subject Headings (LCSH): | Rotaviruses -- Brazil -- São Paulo (State), Rotavirus infections -- Brazil -- São Paulo (State) | ||||
| Journal or Publication Title: | Epidemiology and Infection | ||||
| Publisher: | Cambridge University Press | ||||
| ISSN: | 0950-2688 | ||||
| Official Date: | 1998 | ||||
| Dates: |
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| Volume: | Vol.120 | ||||
| Page Range: | pp. 327-334 | ||||
| DOI: | 10.1017/S0950268898008759 | ||||
| Status: | Peer Reviewed | ||||
| Access rights to Published version: | Open Access (Creative Commons) |
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