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Post-meal glucose peaks at home associate with carotid intima-media thickness in type 2 diabetes
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Esposito, Katherine, Ciotola, Miryam, Carleo, Diego, Schisano, Bruno, Sardelli, Luigi, Di Tommaso, Domenico, Misso, Lucio, Saccomanno, Franco, Ceriello, Antonio and Giugliano, D. (Dario) (2008) Post-meal glucose peaks at home associate with carotid intima-media thickness in type 2 diabetes. Journal of Clinical Endocrinology & Metabolism , Volume 93 (Number 4). pp. 1345-1350. doi:10.1210/jc.2007-2000 ISSN 0021-972x.
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Official URL: http://dx.doi.org/10.1210/jc.2007-2000
Abstract
Context: Two-hour postprandial hyperglycemia is related to chronic complications of diabetes and is currently used in the international guidelines to drive the therapy.
Objective: Our objective was to assess the size and timing of post-meal glucose peaks in the everyday life of type 2 diabetic patients and the relationship with carotid atherosclerosis. Design, Setting, and
Patients: This was an observational study performed in 644 outpatients with type 2 diabetes attending diabetes clinics located in the area of the Campania County, South Italy, who provided complete home blood glucose profiles and centralized carotid intima-media thickness (CIMT) assessment. The study was conducted from 2001-2005. Main Outcome Measures: Incremental glucose peak (IGP) was the maximal incremental increase in blood glucose obtained at any point after the meal. CIMT was assessed by carotid sonography.
Results: The level of glycosylated hemoglobin and CIMT progressively increased across quintiles of IGP (P for trend = 0.01 for both). In univariate analysis, all examined glycemic parameters were significantly correlated with CIMT. IGP (r = 0.40; P = 0.006) showed the strongest correlation with CIMT, which remained significant in multiple linear regression analysis (R-2 = 0.26; P = 0.01). IGP was associated with a significant increase of CIMT in tertiles of glycosylated hemoglobin. IGP occurred within 1 h from the start of the meal in 95% of the entire diabetic population.
Conclusion: IGPs are frequent in the everyday life of patients with type 2 diabetes, occur for most (95%) within 1 h after meal, timing of IGPs is not influenced by treatment (diet or drugs), and IGPs correlate with CIMT.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Non-insulin-dependent diabetes, Hyperglycemia, Glycemic index | ||||
| Journal or Publication Title: | Journal of Clinical Endocrinology & Metabolism | ||||
| Publisher: | Endocrine Society | ||||
| ISSN: | 0021-972x | ||||
| Official Date: | April 2008 | ||||
| Dates: |
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| Volume: | Volume 93 | ||||
| Number: | Number 4 | ||||
| Number of Pages: | 6 | ||||
| Page Range: | pp. 1345-1350 | ||||
| DOI: | 10.1210/jc.2007-2000 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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