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Processing, characterisation, and biocompatibility of zinc modified metaphosphate based glasses for biomedical applications
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Abou Neel, Ensanya A., O'Dell, Luke A., Smith, Mark E. and Knowles, Jonathan C. (2008) Processing, characterisation, and biocompatibility of zinc modified metaphosphate based glasses for biomedical applications. Journal of Materials Science: Materials in Medicine, Vol.19 (No.4). pp. 1669-1679. doi:10.1007/s10856-007-3313-1 ISSN 0957-4530.
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Official URL: http://dx.doi.org/10.1007/s10856-007-3313-1
Abstract
Bulk and structural properties of zinc oxide (0 up to 20 mol%) containing phosphate glasses, developed for biomedical applications, were investigated throughout this study using differential thermal analysis (DTA), differential scanning calorimetry, X-ray powder diffraction and P-31 and Na-23 MAS NMR. Surface wettability and MG63 viability were also considered for surface characterisation of these glasses. The results indicated that incorporation of zinc oxide as a dopant into phosphate glasses produced a significant increase in density; however, the thermal properties presented in glass transition, and melting temperatures were reduced. NaZn(PO3)(3) was detected in the X-Ray Powder Diffraction Analysis (XRD) trace of zinc containing glasses, and the proportion of this phase increased with increasing zinc oxide content. NaCa(PO3)(3) as a second main phase and CaP2O6 in minor amounts were also detected. The P-31 and Na-23 MAS NMR results suggested that the relative abundances of the Q(1) and Q(2) phosphorus sites, and the local sodium environment were unaffected as CaO was replaced by ZnO in this system. The replacement of CaO with ZnO did seem to have the effect of increasing the local disorder of the Q(2) metaphosphate chains, but less so for the Q(1) chain-terminating sites which were already relatively disordered due to the proximity of modifying cations. Glasses with zinc oxide less than 5 mol% showed higher surface wettability, while those with 5 up to 20 mol% showed comparable wettability as zinc oxide free glasses. Regardless of the high hydrophilicity and surface reactivity of these zinc oxide containing glasses, they had lower biocompatibility, in particular 10-20 mol% ZnO, compared to both zinc free glasses and Thermanox (R). This may be associated with the release of significant amount of Zn2+ enough to be toxic to MG63.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > R Medicine (General) T Technology > TP Chemical technology |
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Divisions: | Administration > University Executive Office Faculty of Science, Engineering and Medicine > Science > Physics |
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Library of Congress Subject Headings (LCSH): | Glass in medicine, Biomedical engineering, Biomedical materials, Soluble glass, Ceramics in medicine | ||||
Journal or Publication Title: | Journal of Materials Science: Materials in Medicine | ||||
Publisher: | Springer New York LLC | ||||
ISSN: | 0957-4530 | ||||
Official Date: | April 2008 | ||||
Dates: |
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Volume: | Vol.19 | ||||
Number: | No.4 | ||||
Number of Pages: | 11 | ||||
Page Range: | pp. 1669-1679 | ||||
DOI: | 10.1007/s10856-007-3313-1 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC) | ||||
Version or Related Resource: | Paper presented at: 21st European Conference on Biomaterials, Brighton, England, Sep 09-13, 2007 | ||||
Type of Event: | Conference |
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