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Partial mixture model for tight clustering in exploratory gene expression analysis
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Yuan, Yinyin, Li, Chang-Tsun and Yang, JY (2007) Partial mixture model for tight clustering in exploratory gene expression analysis. In: 7th IEEE International Conference on Bioinformatics and Bioengineering, Boston, USA, 14-17 Oct 2007. Published in: Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, 2007. BIBE 2007. pp. 1061-1065. ISBN 9781424415090. doi:10.1109/BIBE.2007.4375689
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Official URL: http://dx.doi.org/10.1109/BIBE.2007.4375689
Abstract
In this paper we demonstrate the inherent robustness of minimum distance estimator that makes it a potentially powerful tool for parameter estimation in gene expression time course analysis. To apply minimum distance estimator to gene expression clustering, a partial mixture model that can naturally incorporate replicate information and allow scattered genes is formulated specially for tight clustering. Recently tight clustering was proposed as a response for obtaining tighter and thus more informative clusters in gene expression studies. We provide interesting results through data fitting when compared with maximum likelihood estimator using simulated data. The experiments on real gene expression data validated our proposed partial regression clustering algorithm. Our aim is to provide interpretations, discussions and examples that serve as resources for future research.
Item Type: | Conference Item (Paper) | ||||
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Subjects: | R Medicine Q Science > QH Natural history > QH301 Biology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||
Journal or Publication Title: | Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, 2007. BIBE 2007. | ||||
Publisher: | IEEE/Curran Associates Inc. | ||||
ISBN: | 9781424415090 | ||||
Editor: | Yang, MQ and Zhu, MM and Zhang, Y and Arabnia, HR and Deng, Y and Bourbakis, N | ||||
Official Date: | 2007 | ||||
Dates: |
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Number of Pages: | 5 | ||||
Page Range: | pp. 1061-1065 | ||||
DOI: | 10.1109/BIBE.2007.4375689 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Conference Paper Type: | Paper | ||||
Title of Event: | 7th IEEE International Conference on Bioinformatics and Bioengineering | ||||
Type of Event: | Conference | ||||
Location of Event: | Boston, USA | ||||
Date(s) of Event: | 14-17 Oct 2007 |
Data sourced from Thomson Reuters' Web of Knowledge
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