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A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan
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Chappell, M. J. (Michael J.), Evans, Neil D., Errington, Rachel J., Khan, I. A., Campbell, L., Ali, Reza, Godfrey, Keith and Smith, Paul J. (2008) A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan. Computer Methods and Programs in Biomedicine, Vol.89 (No.2). pp. 169-178. doi:10.1016/j.cmpb.2007.11.002 ISSN 0169-2607.
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Official URL: http://dx.doi.org/10.1016/j.cmpb.2007.11.002
Abstract
A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent. By linking the models in this way, rather than using separate (disjoint) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is compared to experimental in vitro cell cycle response data (comprising single cell descriptors for molecular and behavioural events), showing good qualitative agreement for a range of TPT dose levels.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology T Technology > TA Engineering (General). Civil engineering (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Library of Congress Subject Headings (LCSH): | Pharmacokinetics -- Mathematical models, Cell cycle -- Mathematical models, Cancer cells, Cancer -- Treatment | ||||
| Journal or Publication Title: | Computer Methods and Programs in Biomedicine | ||||
| Publisher: | Elsevier Ireland Ltd. | ||||
| ISSN: | 0169-2607 | ||||
| Official Date: | February 2008 | ||||
| Dates: |
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| Volume: | Vol.89 | ||||
| Number: | No.2 | ||||
| Number of Pages: | 10 | ||||
| Page Range: | pp. 169-178 | ||||
| DOI: | 10.1016/j.cmpb.2007.11.002 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||
| Grant number: | 88/E19305 (BBSRC) | ||||
| Title of Event: | Workshop on Nordic Models of Capitalism | ||||
| Location of Event: | Univ Birmingham, Birmingham, ENGLAND | ||||
| Date(s) of Event: | OCT 08-09, 2004 |
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