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Design and non-covalent DNA binding of platinum(II) metallacalix[4]arenes
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Galindo, Miguel A., Olea, David, Angustias Romero, M., Gomez, Julio, del Castillo, Pedro, Hannon, M. J. (Michael J.), Rodger, Alison, Zamora, Felix and Navarro, Jorge A. R. (2007) Design and non-covalent DNA binding of platinum(II) metallacalix[4]arenes. Chemistry - A European Journal, Volume 13 (Number 18). pp. 5075-5081. doi:10.1002/chem.200601581 ISSN 0947-6539.
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Official URL: http://dx.doi.org/10.1002/chem.200601581
Abstract
A set of cyclic tetranuclear complexes of the metallacalix[4]arene type with formula [{Pt(en)(L)}(4)](4+) (en = ethylenediamine; 2 LH=5-chloro-2-hydroxypyrimidine (5-Cl-Hpymo); 3: LH=5-bromo-2-hydroxypyrimidine (5-Br-Hpymo); 4: LH=5-iodo-2-hydroxypyrimidine (5-I-Hpymo)) have been obtained from the reaction between cis-protected square-planar [Pt(en)(H2O)(2)](2+) metal entities and LH in aqueous media. Additionally, the binding properties of 2, 3, 4 and their congener [{Pt(en)(L)}(4)](4+) (1: LH=2-hydroxypyrimidine (Hpymo)) with calf thymus-DNA (ct-DNA) have been studied by using different techniques including circular and linear dichroism (CD and LD, respectively) and UV-visible absorbance spectroscopies, gel electrophoresis, fluorescence competitive-binding studies and atomic force microscopy (AFM). The results are consistent with significant non-covalent interactions taking place between the polynuclear cyclic species and ct-DNA. Moreover, gel electrophoresis, linear dichroism titrations and AFM images of ct-DNA with metallacalixarenes show ct-DNA coiling at low metallacalixarene concentrations and upon subsequent increments in metallacalixarene concentration ct-DNA can be seen to uncoil with concomitant formation of long and inflexible ct-DNA structures.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Chemistry - A European Journal | ||||
Publisher: | Wiley | ||||
ISSN: | 0947-6539 | ||||
Official Date: | June 2007 | ||||
Dates: |
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Volume: | Volume 13 | ||||
Number: | Number 18 | ||||
Number of Pages: | 7 | ||||
Page Range: | pp. 5075-5081 | ||||
DOI: | 10.1002/chem.200601581 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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