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Modelling the control of cell proliferation by an anti-cancer agent
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Ali, Reza, Evans, Neil D., Campbell, Lee, Errington, Rachel J., Godfrey, Keith R., Smith, Paul J. and Chappell, M. J. (Michael J.) (2007) Modelling the control of cell proliferation by an anti-cancer agent. Measurement & Control, Vol.40 (No.1). pp. 12-15. ISSN 0020-2940.
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Abstract
A mathematical model has been developed which describes human cell growth in the presence of topotecan (TPT), an anti-cancer agent. Previously, a model was developed for the pharmacokinetics (PK) of TPT, this provided a description of the activity of TPT and the subsequent delivery of the active form to the nuclear DNA target. This model is described briefly in this paper. The development of a new pharmacodynamic (PD) model for cell growth, based on a well-known cell cycle model is then discussed. The linking of the PK model to the PD model is considered with respect to the modulation of cell growth. Our PK-PD model has good agreement with in vitro experimental data. In a clinical context, it is intended that the model will be used for discovering routes for drug resistance and eventually as a tool for improving drug treatments for patients.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
| Library of Congress Subject Headings (LCSH): | Cells -- Growth -- Mathematical models, Antineoplastic agents -- Mathematical models, Drugs -- Physiological effect -- Mathematical models | ||||
| Journal or Publication Title: | Measurement & Control | ||||
| Publisher: | Sage Publications Ltd. | ||||
| ISSN: | 0020-2940 | ||||
| Official Date: | February 2007 | ||||
| Dates: |
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| Volume: | Vol.40 | ||||
| Number: | No.1 | ||||
| Number of Pages: | 4 | ||||
| Page Range: | pp. 12-15 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Research Councils UK (RCUK) | ||||
| Grant number: | 88/E19305 (BBSRC) |
Data sourced from Thomson Reuters' Web of Knowledge
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