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Regulation of pancreatic beta cell function and viability by adiponectin
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Brown, J. E. P., Digby, J. E., Ward, K. L., Randeva, Harpal S. and Dunmore, S. J. (2006) Regulation of pancreatic beta cell function and viability by adiponectin. In: 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD), Copenhagen, Denmark; Malmoe, Sweden, Sep 14-17, 2006. Published in: Diabetologia, Vol.49 (Suppl.1). pp. 381-382. ISSN 0012-186X.
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Abstract
Obesity is a risk factor for the metabolic syndrome and type 2 diabetes. Adiponectin, a 30kDa adipocyte secreted peptide has been shown to be anti-atherogenic, and anti-inflammatory, as well as affecting insulin resistance and pancreatic beta-cell function. This study investigated the effects of full length and globular adiponectin on pancreatic beta-cell viability, and expression of UCP-2, PDX-1 and LPL genes, as well as studying levels of expression of the adiponectin receptor subtypes 1 and 2 (AdR-1 and AdR-2) and their regulation in the pancreatic BRIN-BD11 beta-cell line.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Diabetologia | ||||
| Publisher: | Springer | ||||
| ISSN: | 0012-186X | ||||
| Official Date: | September 2006 | ||||
| Dates: |
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| Volume: | Vol.49 | ||||
| Number: | Suppl.1 | ||||
| Number of Pages: | 2 | ||||
| Page Range: | pp. 381-382 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | European Association for the Study of Diabetes | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | 42nd Annual Meeting of the European Association for the Study of Diabetes (EASD) | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Copenhagen, Denmark; Malmoe, Sweden | ||||
| Date(s) of Event: | Sep 14-17, 2006 |
Data sourced from Thomson Reuters' Web of Knowledge
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