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Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis
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Kaur, Jaspreet, Adya, Raghu, Tan, Bee K., Chen, Jing and Randeva, Harpal S. (2010) Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis. Biochemical and Biophysical Research Communications, Vol.391 (No.4). pp. 1762-1768. doi:10.1016/j.bbrc.2009.12.150 ISSN 0006-291X.
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Official URL: http://dx.doi.org/10.1016/j.bbrc.2009.12.150
Abstract
Chemerin acting via its distinct G protein-coupled receptor CMKLR1 (ChemR23), is a novel adipokine, circulating levels of which are raised in inflammatory states. Chemerin shows strong correlation with various facets of the metabolic syndrome; these states are associated with an increased incidence of cardiovascular disease (CVD) and dysregulated angiogenesis. We therefore, investigated the regulation of ChemR23 by pro-inflammatory cytokines and assessed the angiogenic potential of chemerin in human endothelial cells (EC). We have demonstrated the novel presence of ChemR23 in human ECs and its significant up-regulation (P < 0.001) by pro-inflammatory cytokines, TNF-α, IL-1β and IL-6. More importantly, chemerin was potently angiogenic, as assessed by conducting functional in-vitro angiogenic assays; chemerin also dose-dependently induced gelatinolytic (MMP-2 & MMP-9) activity of ECs (P < 0.001). Furthermore, chemerin dose-dependently activated PI3K/Akt and MAPKs pathways (P < 0.01), key angiogenic and cell survival cascades. Our data provide the first evidence of chemerin-induced endothelial angiogenesis and MMP production and activity.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Retinoids, Cytokines -- Research, Neovascularization -- Regulation, Vascular endothelial growth factors, Cardiovascular system -- Diseases | ||||
Journal or Publication Title: | Biochemical and Biophysical Research Communications | ||||
Publisher: | Elsevier | ||||
ISSN: | 0006-291X | ||||
Official Date: | 22 January 2010 | ||||
Dates: |
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Volume: | Vol.391 | ||||
Number: | No.4 | ||||
Page Range: | pp. 1762-1768 | ||||
DOI: | 10.1016/j.bbrc.2009.12.150 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | General Charities of the City of Coventry (GCCC) |
Data sourced from Thomson Reuters' Web of Knowledge
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