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Warwick hip trauma study : a randomised clinical trial comparing interventions to improve outcomes in internally fixed intracapsular fractures of the proximal femur : protocol for The WHiT Study

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Griffin, Xavier L., Parsons, Nicholas R., Achten, Juul and Costa, Matthew L. (2010) Warwick hip trauma study : a randomised clinical trial comparing interventions to improve outcomes in internally fixed intracapsular fractures of the proximal femur : protocol for The WHiT Study. BMC Musculoskeletal Disorders, Vol.11 . Article 184. doi:10.1186/1471-2474-11-184 ISSN 1471-2474.

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Official URL: http://dx.doi.org/10.1186/1471-2474-11-184

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Abstract

Background
Controversy exists regarding the optimal treatment for patients with displaced intracapsular fractures of the proximal femur. The recognised treatment alternatives are arthroplasty and internal fixation. The principal criticism of internal fixation is the high rate of non-union; up to 30% of patients will have a failure of the fixation leading to revision surgery. We believe that improved fracture healing may lead to a decreased rate of failure of fixation. We therefore propose to investigate strategies to both accelerate fracture healing and improve fixation that may significantly improve outcomes after internal fixation of intracapsular femoral fractures. We aim to test the clinical effectiveness of the osteoinductive agent platelet rich plasma and conduct a pilot study of a novel fixed-angle fixation system.

Design
We have planned a three arm, single centre, standard-of-care controlled, double blinded, pragmatic, randomised clinical trial. The trial will include a standard two-way comparison between platelet-rich plasma and standard-of-care fixation versus standard-of-care fixation alone. In addition there will be a subsidiary pilot arm testing a fixed-angle screw and plate fixation system.

Item Type: Journal Article
Subjects: R Medicine > RD Surgery
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit
Library of Congress Subject Headings (LCSH): Femur -- Fractures, Internal fixation in fractures, Fractures, Ununited, Blood plasma
Journal or Publication Title: BMC Musculoskeletal Disorders
Publisher: BioMed Central Ltd.
ISSN: 1471-2474
Official Date: 17 August 2010
Dates:
DateEvent
17 August 2010Published
Volume: Vol.11
Page Range: Article 184
DOI: 10.1186/1471-2474-11-184
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Funder: Furlong Research Charitable Foundation, BUPA Foundation
Grant number: TBF-RR10-001 (BUPA)

Data sourced from Thomson Reuters' Web of Knowledge

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